Test measures immune response to improve ovarian cancer diagnosis

(RMIT University) About 300,000 new cases of ovarian cancer are diagnosed globally each year, with about 60% of women dying within five years after diagnosis. A clinical trial has shown testing for a specific immune biomarker could improve diagnosis.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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In conclusion, this study identified TTLL12 as a potential molecular marker for predicting the invasion and progression of OC. PMID: 32211104 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
No abstract available
Source: AJN - Category: Nursing Tags: In the News Source Type: research
Conclusion: Our findings suggested that NMDAR encephalitis might be associated with clear cell renal carcinoma. When patients present with unexplained seizures, neuropsychiatric disorder, or other brain symptoms, clinicians should be careful with paraneoplastic neurological disorders. Early diagnosis and treatment of primary tumors might show improvement.
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
o Gangemi The human microbiota is made up of the fungi, bacteria, protozoa and viruses cohabiting within the human body. An altered microbiota can provoke diseases such as cancer. The mechanisms by which a modified microbiota can intervene in the onset and progression of neoplastic diseases are manifold. For instance, these include the effects on the immune system and the onset of obesity. A different mechanism seems to be constituted by the continuous and bidirectional relationships existing between microbiota and miRNAs. MiRNAs emerged as a novel group of small endogenous non-coding RNAs from that control gene expres...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Liver cancer is the third most common cause of cancer related death in the World. From an epidemiological point of view the risk factors associated to primary liver cancer are mainly viral hepatitis infection and alcohol consumption. Even though there is a clear correlation between liver inflammation, cirrhosis and cancer, other emerging liver diseases (like fatty liver) could also lead to liver cancer. Moreover, the liver is the major site of metastasis from colon, breast, ovarian and other cancers. In this review we will address the peculiar status of the liver as organ that has to balance between tolerance and immune ac...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
(University of Colorado Anschutz Medical Campus) Study shows CPT1A may help ovarian cancer cells spread, also resist chemo. Group moves toward clinical trial of CPT1A inhibitor, etomoxir, in chemo-resistant ovarian cancer.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
(Aarhus University) Malignant ovarian cancer is insidious: Known and feared for vague and uncharacteristic symptoms that often mean the disease is discovered so late that on average only four out of six patients are still alive after five years. Researchers from Aarhus University, Denmark, are hoping to change this situation in the future together with research colleagues from France and the UK.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
The original version of this article unfortunately contained a mistake.
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
IJERPH, Vol. 17, Pages 2213: Comparing Paclitaxel–Carboplatin with Paclitaxel–Cisplatin as the Front-Line Chemotherapy for Patients with FIGO IIIC Serous-Type Tubo-Ovarian Cancer International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17072213 Authors: Huang Cheng Lee Huang Lee Chang Wang The use of weekly chemotherapy for the treatment of patients with advanced-stage serous-type epithelial Tubo-ovarian cancer (ETOC), and primary peritoneal serous carcinoma (PPSC) is acceptable as the front-line postoperative chemotherapy after primary cytoreductive surger...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
This study aimed to investigate prognostic biomarkers of HGSOC through proteomic analysis. We conducted label-free liquid chromatography-mass spectrometry using chemotherapy-naïve, fresh-frozen primary HGSOC specimens, and compared the results between a favorable prognosis group (progression-free survival (PFS) ≥ 18 months, n = 6) and a poor prognosis group (PFS < 18 months, n = 6). Among 658 differentially expressed proteins, 288 proteins were upregulated in the favorable prognosis group and 370 proteins were upregulated in the poor prognosis group. Using hierarchical clustering, we selected &al...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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