ORATOR study : Surgery or radiotherapy for oropharyngeal carcinoma in the context of HPV?
[ORATOR study : Surgery or radiotherapy for oropharyngeal carcinoma in the context of HPV?] HNO. 2020 Feb 14;: Authors: Hoffmann TK PMID: 32060569 [PubMed - as supplied by publisher]
Publication date: Available online 9 October 2020Source: Pathology - Research and PracticeAuthor(s): Borislav A. Alexiev, Farres Obeidin, Daniel N. Johnson, Brian S. Finkelman, Rebecca Prince, Shaan N. Somani, Esther Cheng, Sandeep Samant
Epithelial–myoepithelial carcinoma (EMC) is a rare neoplasm of the salivary glands. The aim of this study is to review and evaluate clinicopathological features and treatment of EMC of salivary gland for better sensitivity and specificity of the diagnosis. The clinical and pathological data of the 10 salivary gland EMC cases from 2008 to 2017 were analyzed. Six cases of EMC were diagnosed to be originated from parotid gland and 4 cases were from the minor salivary gland including palate, tongue, and oropharynx. Seven cases were performed radical surgery and 3 cases had radiotherapy postoperation, 2 cases had a loca...
Conditions: Human Papillomavirus-Related Carcinoma; Oropharyngeal Cancer Intervention: Radiation: Hypofractionated intensity modulated radiotherapy Sponsor: University of Texas Southwestern Medical Center Not yet recruiting
Oropharyngeal cancer is a subtype of head and neck squamous cell carcinoma that is associated with unique risk exposures like consumption of smokeless tobacco and areca nut and is highly prevalent in the northeastern region of India, especially Meghalaya. However, the underlying epigenetic and transcriptomic changes in this cancer type is yet to be delineated. We have undertaken a study on genome wide somatic alterations in the DNA methylation and transcriptome in oropharyngeal cancer patients from this region using genome wide techniques in paired tumors and adjacent normal tissues. By using integrative approaches, we hav...
Conditions: Clinical Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Clinical Stage IV HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage III HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8; Pathologic Stage IV HPV-Mediated (p16-Positive ) Oropharyngeal Carcinoma AJCC v8; Recurrent Head and Neck Squamous Cell Carcinoma; Recurrent Hypopharyngeal Squamous Cell Carcinoma; Recurrent Laryngeal Squamous Cell Carcinoma; Recurrent Oral ...
Opinion statementHead and neck cancer of unknown primary (HNCUP) is increasingly encountered in both community otolaryngology practice and the academic head and neck cancer program. A stepwise diagnostic evaluation will identify many primary sites. However, true HNCUP remains common in high-volume practices after appropriate examination, imaging, and biopsies. The prognosis for the majority of the patients is good, owing to the common association with high-risk HPV, and putative oropharyngeal primary origin. With high oncologic control rates, judicious treatment selection is essential to optimize functional outcomes.
CONCLUSIONS: CT-based radiomics may be useful in predicting human papillomavirus status and overall survival in patients with oropharyngeal squamous cell carcinoma.
Publication date: Available online 1 October 2020Source: European Journal of RadiologyAuthor(s): Keita Onoue, Noriyuki Fujima, Vanesa Carlota Andreu-Arasa, Bindu Setty, Muhammad Mustafa Qureshi, Osamu Sakai
Condition: Oropharyngeal Squamous Cell Carcinoma Interventions: Other: Transoral Robotic Surgery (TORS) or Radiotherapy; Other: Chemotherapy and Low-Dose Radiotherapy; Other: Chemotherapy and High-Dose Radiotherapy; Drug: Paclitaxel; Drug: Carboplatin Sponsor: University of Chicago Not yet recruiting