Onset of Effect, Changes in Airflow Obstruction and Lung Volume, and Health-Related Quality of Life Improvements with Benralizumab for Patients with Severe Eosinophilic Asthma: Phase IIIb Randomized, Controlled Trial (SOLANA)

Source: Journal of Asthma and Allergy - Category: Allergy & Immunology Tags: Journal of Asthma and Allergy Source Type: research

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Publication date: Available online 5 April 2020Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Schleich Florence, Vaia Elleni-Sofia, Pilette Charles, Vandenplas Olivier, Halloy Jean-Luc, Michils Alain, Peche Rudy, Hanon Shane, Louis Renaud, Michel Olivier
Source: The Journal of Allergy and Clinical Immunology: In Practice - Category: Allergy & Immunology Source Type: research
MONDAY, April 6, 2020 -- People taking a certain class of steroids for inflammatory conditions such as asthma, allergies and arthritis may be at increased risk from the new coronavirus, experts say. Glucocorticoid medications suppress the immune...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
AbstractPurpose of ReviewThe review provides an update on the diagnosis, pathogenesis, and treatment of cutaneous lupus erythematosus (CLE).Recent FindingsDiagnostic challenges exist in better defining CLE as an independent disease distinct from systemic lupus erythematosus with cutaneous features and further classifying CLE based on clinical, histological, and laboratory features. Recent mechanistic studies revealed more genetic variations, environmental triggers, and immunologic dysfunctions that are associated with CLE. Drug induction specifically has emerged as one of the most important triggers for CLE. Treatment opti...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
AbstractPurpose of ReviewIdiopathic pulmonary hemosiderosis (IPH) is one of the rarest and least understood causes of pulmonary hemorrhage in children. Illustrated by a complex case presentation, we discuss the clinical manifestations, diagnosis, pathology, proposed etiologies, and treatment of this rare disease. We also compare IPH with anti-glomerular basement membrane antibody syndrome (anti-GBM disease), another rare causes of pediatric pulmonary hemorrhage.Recent FindingsRecent retrospective studies regarding IPH along with advanced immunotherapy have led to an improved understanding of how to best treat this conditio...
Source: Current Allergy and Asthma Reports - Category: Allergy & Immunology Source Type: research
Ingredients in toothpaste may cause allergic and irritant contact stomatitis (Table I). Flavourings are most commonly incriminated, as they are present in 95% of toothpastes.1 Less frequently, cinnamon, fluoride and Anethole (Anise camphor) have been suggested to cause local irritation.2,3 Pruritis and flexural dermatitis to toothpaste has been reported in a 50-year-old woman sensitized to stannous fluoride (SnF2) on patch testing.4
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Cephalosporins are one of the most prescribed classes of antibiotics1 and 1-3% of population report a cephalosporin allergy2. They are beta-lactam antibiotics and their chemistry, mechanism of action and toxicity are similar to penicillins. The most common classification of cephalosporins is by generation. There are five generations of cephalosporins.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Oral Allergy Syndrome (OAS) is a specific type of allergic reaction that mainly occurs after the consumption of raw fruit, vegetables, and nuts.1 In adults, OAS represents the most common allergic reaction to food, affecting patients with pollen sensitization due to homology between plant proteins.2 It is a complex syndrome with diagnostic and therapeutic challenges, requiring comprehensive history taking and examination. We discuss a case of OAS following Mojo (sauce used in Cuban food) ingestion, the diagnostic challenge, and our approach for its management.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
The Learning Early About Peanut Allergy (LEAP) trial and other studies suggest early peanut (PN) introduction prevents PN allergy in at-risk infants.1,2 In addition, PN-oral immunotherapy (PN-OIT) shows increased rates of sustained unresponsiveness in children4 mm.1 Guidelines recommend PN introduction or oral food challenge (OFC) in infants who have skin prick tests ≤7 mm and do not specifically address management of infants with SPTs>7 mm (or high PN-IgE levels).
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Letters Source Type: research
Source: Journal of Allergy and Clinical Immunology - Category: Allergy & Immunology Authors: Source Type: research
Short courses of systemic corticosteroids (SCS), both oral and injectable, are very effective for the resolution of acute asthma symptoms, including exacerbations. However, the benefits of SCS, even short courses, must be balanced against the impact of their side-effects. While the adverse consequences of long-term use are widely recognised, there appears to be a perception in the medical community that short courses of SCS are safe. Limited but growing evidence in the literature suggests that even very brief dosing periods (3–7 days) of SCS are enough to cause significantly negative outcomes for patients. Short...
Source: European Respiratory Review - Category: Respiratory Medicine Authors: Tags: Asthma and allergy Reviews Source Type: research
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