European Society for Immunodeficiencies (ESID) and European Reference Network on Rare Primary Immunodeficiency, Autoinflammatory and Autoimmune Diseases (ERN RITA) Complement Guideline: Deficiencies, Diagnosis, and Management

AbstractThis guideline aims to describe the complement system and the functions of the constituent pathways, with  particular focus on primary immunodeficiencies (PIDs) and their diagnosis and management. The complement system is a crucial part of the innate immune system, with multiple membrane-bound and soluble components. There are three distinct enzymatic cascade pathways within the complement system, the classical, alternative and lectin pathways, which converge with the cleavage of central C3. Complement deficiencies account for ~5% of PIDs. The clinical consequences of inherited defects in the complement system are protean and include increased susceptibility to infection, autoimmune diseases (e.g ., systemic lupus erythematosus), age-related macular degeneration, renal disorders (e.g., atypical hemolytic uremic syndrome) and angioedema. Modern complement analysis allows an in-depth insight into the functional and molecular basis of nearly all complement deficiencies. However, therapeutic opt ions remain relatively limited for the majority of complement deficiencies with the exception of hereditary angioedema and inhibition of an overactivated complement system in regulation defects. Current management strategies for complement disorders associated with infection include education, fami ly testing, vaccinations, antibiotics and emergency planning.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research

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In conclusion, the present findings indicate that MYBL2 may be used as an independent prognostic factor in patients with ccRCC. PMID: 32218829 [PubMed - as supplied by publisher]
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research
Human trials will begin imminently – but even if they go well and a cure is found, there are many barriers before global immunisation is feasibleCoronavirus – latest updatesSee all our coronavirus coverageEven at their most effective – and draconian – containment strategies have only slowed the spread of the respiratory disease Covid-19. With the World Health Organization finally declaring a pandemic, all eyes have turned to the prospect of a vaccine, because only a vaccine can prevent people from getting sick.About 35 companies and academic institutions are racing to create such a vaccine, at least...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Vaccines and immunisation Medical research Microbiology Science World news Health Society Source Type: news
Authors: Petrella TM, Fletcher GG, Knight G, McWhirter E, Rajagopal S, Song X, Baetz TD Abstract Background: Previous versions of the guideline from the Program in Evidence-Based Care (pebc) at Ontario Health (Cancer Care Ontario) recommended that the use of high-dose interferon alfa 2b therapy be discussed and offered to patients with resected cutaneous melanoma with a high risk of recurrence. Subsequently, several clinical trials in patients with resected or metastatic melanoma found that immune checkpoint inhibitors and targeted therapies have a benefit greater than that with interferon. It was therefore conside...
Source: Current Oncology - Category: Cancer & Oncology Tags: Curr Oncol Source Type: research
Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2. Click arrow to play Download TWiV 595 (71 MB .mp3, 117 min) Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Show notes at microbe.tv/twiv
Source: virology blog - Category: Virology Authors: Tags: This Week in Virology antiviral coronavirus COVID-19 diagnostic test pandemic SARS-CoV-2 vaccine viruses Source Type: blogs
Daniel Griffin MD joins TWiV from a hospital parking lot to provide updates on COVID-19 diagnostics, clinical picture, and therapeutics, and then the TWiV team continues coverage of the coronavirus pandemic caused by SARS-CoV-2. Hosts: Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler Guest: Daniel Griffin, MD Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Tocilizumab (Wiki) Nares swab for SARS-CoV-2 (Star Trib) US SARS-CoV-2 epidemic curve (CDC) Cleaning and disinfecting (CDC) Cleaning fru...
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Authors: Zhang Y, Hu M, Wei D, Zhang H, Chu B, Xu HM, Wang T Abstract Both the herpes zoster virus and suid herpesvirus type 1 (SuHV-1) belong to the Varicellovirus genus of the α-herpesviridae subfamily. They may cause opportunistic infections especially in patients with kidney diseases, varying from latent illness to overt lethality. Under these circumstances, impaired renal function is both the culprit for and victim of the infection. However, fulminant eruption of severe skin herpes zoster in lupus nephritis (LN) patients under prolonged immunosuppressive therapy is rare and even more rarely seen is the S...
Source: International Journal of Medical Sciences - Category: Biomedical Science Tags: Int J Med Sci Source Type: research
We examined provider and practice characteristics associated with a sizable number of HPV vaccine-hesitant parents (>10%), providers ’ confidence in responding to specific vaccine concerns, and use of vaccine dismissal policies.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
The American Society for Colposcopy and Cervical Pathology (ASCCP) has recommended earlier cervical cancer screening in high-risk immunocompromised patients under 30 years of age, including those with systemic lupus erythematous (SLE) within 1 year of immunosuppression (IS) and/or within 1 year of coitarche. High risk patients with SLE are defined as those on 2 or more IS drugs. The purpose of this study was to examine pap results among SLE adolescents.
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
Intrauterine devices (IUDs) are safe and highly effective methods of contraception as well as a reliable means of menstrual suppression. Over 100 million women use IUDs worldwide and yet there is limited information on their use in women undergoing chemotherapy despite the unmet need for contraception and menstrual suppression in this population. Avoidance of IUDs in this population is secondary to concern regarding infectious morbidity such as an increased risk of pelvic infection. However, it has limited but demonstrated efficacy in other immunocompromised populations such as women with HIV and women with systemic lupus erythematosus (SLE).
Source: Journal of Pediatric and Adolescent Gynecology - Category: OBGYN Authors: Source Type: research
One detects past infection, the other finds current viral load – but there’s a shortage of staff trained to carry them outCoronavirus – latest updatesSee all our coronavirus coverageOnly by implementing carefully controlled programmes that use two very differentCovid-19 test kits will it be possible to predict how the disease will affect the country, researchers have revealed.Scientists emphasised the need to understand, as quickly as possible, where and when new cases of infection were appearing. At the same time, it was vital to pinpoint individuals who had already been infected, possibly without realis...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Vaccines and immunisation Infectious diseases Medical research Science Society Health Microbiology Source Type: news
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