Viruses, Vol. 12, Pages 222: Late-Relapsing Hepatitis after Yellow Fever
Viruses, Vol. 12, Pages 222: Late-Relapsing Hepatitis after Yellow Fever
Viruses doi: 10.3390/v12020222
Authors:
Izabela Maurício Rezende
Leonardo Soares Pereira
Jordana Rodrigues Barbosa Fradico
Marcelo Antônio Pascoal Xavier
Pedro Augusto Alves
Ana Carolina Campi-Azevedo
Elaine Speziali
Lívia Zignago Moreira dos Santos
Natalia Soares Albuquerque
Indiara Penido
Tayrine Araujo Santos
Ana Paula Dinis Ano Bom
Andrea Marques Vieira da Silva
Camilla Bayma Fernandes
Carlos Eduardo Calzavara
Erna Geessien Kroon
Olindo Assis Martins-Filho
Andréa Teixeira-Carvalho
Betânia Paiva Drumond
One patient presented hyporexia, asthenia, adynamia, and jaundice two months after acute yellow fever (YF) onset; plus laboratory tests indicating hepatic cytolysis and a rebound of alanine and aspartate transaminases, and total and direct bilirubin levels. Laboratory tests discarded autoimmune hepatitis, inflammatory or metabolic liver disease, and new infections caused by hepatotropic agents. Anti-YFV IgM, IgG and neutralizing antibodies were detected in different times, but no viremia. A liver biopsy was collected three months after YF onset and tested positive for YFV antigens and wild-type YFV-RNA (364 RNA-copies/gram/liver). Transaminases and bilirubin levels remained elevated for five months, and the arresting of symptoms persisted for six months after the acute YF onset. Several serum chemokines, cytokines, and growth factors were measured. A sim...
Source: Viruses - Category: Virology Authors: Izabela Maur ício Rezende Leonardo Soares Pereira Jordana Rodrigues Barbosa Fradico Marcelo Ant ônio Pascoal Xavier Pedro Augusto Alves Ana Carolina Campi-Azevedo Elaine Speziali L ívia Zignago Moreira dos Santos Natalia Soares Albuquerque Indiara Peni Tags: Case Report Source Type: research
More News: Autoimmune Disease | Bilirubin | Hepatitis | Jaundice | Laboratory Medicine | Liver | Liver Disease | Study | Urology & Nephrology | Virology | Yellow Fever