Pathogenesis of obstructive sleep apnea in individuals with the COPD  + OSA Overlap syndrome versus OSA alone

This is the first study to comprehensively measure both anatomical and non ‐anatomical OSA traits during sleep in those with COPD + OSA (Overlap syndrome) and compare them to those with OSA alone. No consistent differences were found between the two groups, while worsened lung function did impact upper airway function and control of breathing. These findings have impli cations towards mechanisms underlying OSA, as well as management of sleep apnea. AbstractOverlap syndrome (OVS) is the concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), and is associated with poor outcomes. We hypothesized that physiological changes in COPD may affect the pathogenesis of OSA in important ways. We therefore sought to measure the anatomical and nonanatomical OSA traits in individuals with OVS and compare to those with OSA alone. Patients with established OVS were recruited, along with age, gender, and BMI matched OSA only controls. Smoking and relevant comorbidities or medications were excluded. Subjects underwent baseline polysomnography followed by an overnight physiological research study to measure the OSA traits (Veupnea, Varousal, Vpassive, Vactive, and loop gain). Fifteen subjects with OVS and 15 matched controls with OSA alone were studied (overall 66  ± 8 years, 20% women, BMI 31 ± 4 kg/m2, apnea ‐hypopnea index 49 ± 36/hr). Mixed‐modeling was used to incorporate each...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research

Related Links:

Authors: Wang TY, Tsai MH, Ni YL, Lin TY, Huang SY, Lo YL Abstract The aim of this study was to develop a simplified screening questionnaire to detect the existence of severe obstructive sleep apnea (OSA) in chronic obstructive pulmonary disease (COPD) patients to reduce mortality and hospitalization rates. Seventy-seven stable Asian COPD patients aged 69.2 ± 11.5 years were retrospectively analyzed into the development group. The simplified screening questionnaire was developed from factors identified from sleep surveys and demographic data to predict severe OSA. Receiver operating char...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
This is the first study to comprehensively measure both anatomical and non ‐anatomical OSA traits during sleep in those with COPD + OSA (Overlap syndrome) and compare them to those with OSA alone. No consistent differences were found between the two groups, while worsened lung function did impact upper airway function and control of breathing. These findings have impli cations towards mechanisms underlying OSA, as well as management of sleep apnea. AbstractOverlap syndrome (OVS) is the concurrence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), and is associated with poor outc...
Source: Physiological Reports - Category: Physiology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Conclusions: The LSG is an effective method of treatment in all areas of metabolic syndrome, provides a significant positive clinical outcome in obesity-related comorbidities and induces desirable changes in inflammatory, kidney and liver related biomarkers. PMID: 32117497 [PubMed]
Source: Videosurgery and Other Miniinvasive Techniques - Category: Surgery Tags: Wideochir Inne Tech Maloinwazyjne Source Type: research
AbstractPurpose of ReviewThe main objective of the 1st part of this review is to demonstrate that a better understanding of comorbidities such as COPD, obstructive sleep apnea, thyroid dysfunction, cardiorenal syndrome, its pathophysiological and therapeutic implications, impact on the management of FH by interfering with its survival, and quality of life of patients.Recent FindingsThe prevalence of heart failure will increase 46% from 2012 to 2030, resulting in>  8 million people ≥ 18 years of age. This disease has a large burden of noncardiovascular comorbidities, which may increase the risk of m...
Source: Current Emergency and Hospital Medicine Reports - Category: Emergency Medicine Source Type: research
Shruti Singh, Sara Z Khan, Dilbagh Singh, Sameer Verma, Arunabh TalwarLung India 2020 37(2):151-157 Overnight pulse oximetry (OPO) has proven to be an effective and beneficial technique to determine the cardiorespiratory status of patients in both the inpatient and outpatient settings. It is a cheap, safe, reliable, simple, and accurate method of patient monitoring as compared to the expensive and labor-intensive method of multichannel polysomnography for detecting sleep-disordered breathing. It provides accurate information about patient's oxygenation status and also helps in monitoring the response to continuous pos...
Source: Lung India - Category: Respiratory Medicine Authors: Source Type: research
We present a case of acute hypercapnic exacerbation of COPD, intolerant to non-invasive ventilation, showing response and improvement on use of HFNC. This case highlights this potential mechanisms and prospects for the same. PMID: 31970968 [PubMed - in process]
Source: Monaldi Archives for Chest Disease - Category: Respiratory Medicine Tags: Monaldi Arch Chest Dis Source Type: research
Authors: Jen R, Orr JE, Li Y, DeYoung P, Smales E, Malhotra A, Owens RL Abstract The co-existence of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA), termed the overlap syndrome (OVS), is associated with adverse outcomes that may be reversed with treatment. However, diagnosis is limited by the apparent need for in-laboratory polysomnography (PSG). WatchPAT is a portable diagnostic device that is validated for the diagnosis of OSA that might represent an attractive tool for the diagnosis of OVS.Subjects with established COPD were recruited from a general population. Subjects underwent ...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
Abstract A good night's sleep is a prerequisite for sustainable mental and physical health. Sleep disorders, including sleep disordered breathing, insomnia and sleep related motor dysfunction (e.g., restless legs syndrome), are common in patients with chronic obstructive pulmonary disease (COPD), especially in more severe disease. COPD is commonly associated with multimorbidity, and sleep disorders as a component of this multimorbidity spectrum have a further negative impact on COPD-related comorbidities. Indeed, concomitant diseases in COPD and in obstructive sleep apnea (OSA) are similar, suggesting that the com...
Source: European Journal of Internal Medicine - Category: Internal Medicine Authors: Tags: Eur J Intern Med Source Type: research
AbstractPurpose of ReviewThe purpose of this review article is to provide an overview of sleep and pulmonary comorbidities in patients with psoriasis and summarize important recent findings.Recent FindingsEvidence continues to show that patients with psoriasis experience greater chronic sleep impairment when compared to healthy counterparts. In addition to other comorbidities seen in psoriasis patients, including cardiovascular disease, obesity, and diabetes, obstructive sleep apnea and chronic obstructive pulmonary disease have increased frequency in this population.SummarySleep and pulmonary comorbidities in psoriasis co...
Source: Current Dermatology Reports - Category: Dermatology Source Type: research
Authors: Shah A, Ayas N, Tan WC, Malhotra A, Kimoff J, Kaminska M, Aaron SD, Jen R Abstract Small studies have suggested that patients with chronic obstructive pulmonary disease (COPD) have poor sleep quality. Our aim was to examine the prevalence of subjective sleep-related complaints and predictors of poor sleep quality in a large community-based COPD cohort. We analyzed cross-sectional data on sleep questionnaire responses from the Canadian Cohort of Obstructive Lung Disease (CanCOLD) study, a population-based, prospective longitudinal cohort study across Canada. The cohort comprises a COPD group and two matched...
Source: COPD: Journal of Chronic Obstructive Pulmonary Disease - Category: Respiratory Medicine Tags: COPD Source Type: research
More News: Chronic Obstructive Pulmonary | Obstructive Sleep Apnea | Physiology | Sleep Apnea | Sleep Disorders | Sleep Medicine | Smokers | Study | Women