Contributing factors and short-term surgical outcomes of patients with early-onset rectal cancer

Publication date: Available online 16 February 2020Source: The American Journal of SurgeryAuthor(s): Agnes Ewongwo, Mohammad Hamidi, Zana Alattar, Oluwatosin P. Ayotunde, Hina A. Tiwari, Emad Elquza, Aaron Scott, Kamil Hanna, Valentine NfonsamAbstractIntroductionThe aim of this study was to evaluate patient factors that contribute to increased incidence of early onset rectal cancer and analyze the short-term surgical outcomes of patients undergoing surgery.MethodsA 2-year review (2015–2016) of the ACS-NSQIP included patients with rectal cancer who underwent surgical management. Patients were stratified into early-onset RC (
Source: The American Journal of Surgery - Category: Surgery Source Type: research

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Publication date: Available online 3 April 2020Source: European Journal of Surgical OncologyAuthor(s): Meike J. van Harten, Emma B. Greenwood, Sergei Bedrikovetski, Nagendra N. Dudi-Venkata, Ronald A. Hunter, Hidde M. Kroon, Tarik Sammour
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionOur dataset suggests that both CC and RC events may lead to a significantly increasing number of deaths in the Brazilian male population in coming years.
Source: Journal of Gastrointestinal Cancer - Category: Cancer & Oncology Source Type: research
CONCLUSION: To our knowledge, our study is the first study to investigate the effects of Xelox treatment on the expression levels of MACC1, FBXW7 and FLNA genes in non-metastatic colorectal cancer patients in Turkey. PMID: 32232196 [PubMed]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: North Clin Istanb Source Type: research
AbstractBackgroundThe evaluation of lymph nodes in rectal cancer dictates treatment. The goals of this study are to characterize the contemporary rate of lymph node metastasis in early stage rectal cancer and to re-investigate histologic factors that predict positive lymph nodes.Materials and MethodsUsing the National Cancer Database, we identified patients with clinical stage I rectal adenocarcinoma. Multivariable logistic regression was used to determine risk factors for lymph node positivity.Results12.2% of patients with T1 tumors and 18.0% of patients with T2 tumors had positive lymph nodes. For T1 tumors, positive lym...
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
This study assessed the utility and safety of robot-assisted ISR by comparing groups of patients who underwent low anterior resection (LAR) with or without ISR and ISR extent.MethodsThis study enrolled 897 patients who underwent curative LAR between 2010 and 2017. Patients were divided into those who did (ISR+) and did not (ISR −) undergo ISR, with the former group subdivided by ISR extent (partial, subtotal, and total). Tumor recurrence and survival were compared in the two groups by one-to-one nearest neighbor matching (218 patients each).ResultsRobot-assisted ISR was performed via an entirely transabdominal approa...
Source: Surgical Endoscopy - Category: Surgery Source Type: research
AbstractDespite large strides in molecular oncology, surgery remains the bedrock in the management of visceral cancer. The primacy of surgery cannot be understated and a mesenteric (i.e. ontogenetic) approach is particularly beneficial to patients. Heald greatly advanced the management of rectal cancer with his description of the anatomical foundation of total mesorectal excision (TME), dramatically improving outcomes worldwide with this mesenteric-based approach. Moreover, complete mesocolic excision (CME) based on similar principles is becoming popular. Introduced by Hohenberger, CME resembles TME insofar as it emphasise...
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
The rapid spread of COVID19 infection across the globe is causing a health care emergency.
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Short Communication Source Type: research
AbstractPurpose of ReviewTo summarize the current available treatments for stage I rectal cancer and the evidence that supports them.Recent FindingsRadical surgery, or total mesorectal excision (TME) without neoadjuvant therapy, reports excellent oncologic outcomes, with 5-year disease-free survival of approximately 95%. Alternative therapies include local excision, which has acceptable long-term outcomes in some low-risk T1 tumors; but overall local excision, with or without additional chemotherapy or radiation, generally reports 5-year disease-free survival less than TME alone. New research is showing complete clinical r...
Source: Current Oncology Reports - Category: Cancer & Oncology Source Type: research
AbstractAlthough the application of laparoscopic rectal surgery has been widely accepted by accumulated evidence, it remains technically difficult in some cases of obesity, narrow male pelvis, bulky tumors, or involvement of adjacent organs. After robotic rectal surgery has been covered by the health insurance system in Japan since April 2018, we have employed robotic rectal surgery for an increasing number of cases by taking advantages of its 3D vision and wrist function. When a colorectal cancer involves the urinary bladder, the surgical treatment of choice is an anterior resection with en bloc (partial or total) bladder...
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
ConclusionsThe transanal/perineal endoscopic approach may have some benefits for extended pelvic surgery for recurrent rectal cancer.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
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