The association between vitamin D deficiency and hospitalization outcomes in pediatric patients with sickle cell disease

Publication date: Available online 15 February 2020Source: Blood Cells, Molecules, and DiseasesAuthor(s): Brande Brown, Kathleen Long, Levon Agdere, Jolanta Kulpa, Sara Zarzoso-Fernandez, Deepak Choudhary, Revathy SundarumAbstractBackgroundWhile there is a known association between low vitamin D levels and increased chronic pain in patients with Sickle Cell Disease (SCD), there are no reported studies evaluating the relationship of vitamin D levels and hospitalization outcomes in this population. The aim of this study was to assess this relationship with hospitalization outcomes defined as the number of emergency room (ER) visits, hospital admissions for pain crisis, and length of hospital stay.DesignA retrospective chart review of all pediatric patients with SCD (1–21 years old) was performed from January 2015 to January 2016 in an urban-based hospital setting (n = 134). Those with at least one reported Vitamin D level who maintained follow up during the time studied were enrolled (n = 90). Patient hospitalizations rates were compared between vitamin D deficiency (20 ng/ml).ResultsPatients with both SCD and vitamin D deficiency were more likely to have at least one Emergency Room visit (p 
Source: Blood Cells, Molecules, and Diseases - Category: Hematology Source Type: research

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Source: Journal of Acupuncture and Meridian Studies - Category: Complementary Medicine Source Type: research
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Source: Journal of Pain Research - Category: Anesthesiology Tags: Journal of Pain Research Source Type: research
Jeffrey A. SingerBack in November the Centers for Disease Control and Prevention announced a “breakthrough” in its investigation into the cause of what is now called EVALI (e‑cigarette vaping associated lung injury): fluid samples from patients revealed the overwhelming majority of cases were due to Vitamin E acetate, used as the solvent in THC ‐​containing vaping liquids. I argued that this discovery provided yet another reason to legalize cannabis.Because cannabis is federally banned, most THC vapers use bootleg cartridges obtained on the black market. Shortly after the discovery that inhaling...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
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Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness #WorldHealthDay brain burnout cognition Cortisol GAS General Adaptation Syndrome homeostasis memory neurobiology neurological exhaustion Stress Source Type: blogs
Publication date: Available online 6 April 2020Source: Clinical Epidemiology and Global HealthAuthor(s): Shally Awasthi, Avivar Awasthi
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Firefighters are an understudied population that reports high rates of alcohol use and hazardous drinking. Pain, which is also commonly experienced by firefighters, may be associated with alcohol use and alcohol use motives, as research among the general p...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Alcohol and Other Drugs Source Type: news
Conditions:   Covid19;   Pregnancy Related;   Vitamin C Deficiency Intervention:   Drug: High dose vitamin C Sponsor:   Kanuni Sultan Suleyman Training and Research Hospital Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
CONCLUSION: In children with SCD, there is a possible association between depressed serum vitamin D levels and increased frequency of acute pain episodes. Vitamin D supplements should be considered in patients with low levels and frequent episodes of pain. PMID: 28270033 [PubMed - as supplied by publisher]
Source: Paediatrics and international child health - Category: Pediatrics Tags: Paediatr Int Child Health Source Type: research
CONCLUSIONS: We included only one low-quality clinical study which had a high risk of bias with regards to incomplete outcome data. Therefore, we consider that the evidence is not of sufficient quality to guide clinical practice. Until further evidence becomes available, clinicians should consider the relevant existing guidelines for vitamin D supplementation (e.g. the Endocrine Society Clinical Practice Guidelines) and dietary reference intakes for calcium and vitamin D (e.g. from the USA Institute of Medicine). Evidence of vitamin D supplementation in sickle cell disease from high quality studies is needed. Well-designed...
Source: Cochrane Database of Systematic Reviews - Category: Journals (General) Authors: Tags: Cochrane Database Syst Rev Source Type: research
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