Severity grading assessment classifications for both insulin resistance syndrome and status of pancreatic beta islet cells’ function in clinical practice using homeostasis model assessment method indices

This article aims to classify the severity grading assessments for both insulin resistance (IR) syndrome and status of pancreatic beta (β) islet cells’ function using the homeostasis model assessment method (that is; homeostasis model assessment-insulin resistance [HOMA-IR] and homeostasis model assessment-pancreatic beta (β) islet cells’ function [HOMA-B] indices) with the focus of disseminating this information rapidly for clinical use by physicians in their patients with dysfunctional regulation of glucose metabolism. It will also assist clinicians to prevent and screen for these individuals who are significantly at high risk for insulin resistance (IR) syndrome and impair pancreatic beta (β) islet cells’ function thereby alleviating the risk for associated comorbidities. Insulin resistance (IR) syndrome and pancreatic beta (β) islet cells’ dysfunction with accompanied insufficiency form two major important and crucial factors in the aetiology and pathogenesis of frank type 2 diabetes mellitus (type 2 DM). The pathophysiological process of insulin resistance (IR) syndrome can either be a compensatory or uncompesatory phase response phenomenon, depending on the extent of biochemical response and effect elicited by the pancreatic beta (β) islet cells to secrete insulin. The alteration mechanisms that underlie the pathophysiological processes and biochemical responses that occur during the onset or induction of peripheral IR ca...
Source: Canadian Journal of Diabetes - Category: Endocrinology Source Type: research

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AbstractSitagliptin attenuates left ventricular (LV) dysfunction and may improve oxygen uptake in animals. The effects of sitagliptin on oxygen uptake (VO2) and exercise hemodynamics have been unclear in patients with type 2 diabetes mellitus (T2DM) and coronary artery disease (CAD). Thirty patients with T2DM and CAD were randomized into a sitagliptin (50 mg/day) or voglibose (0.6 mg/day) group. Patients underwent maximal cardiopulmonary exercise testing. VO2 and hemodynamics were evaluated at rest, anaerobic threshold and peak exercise. Resting LV diastolic function (E ’, peak early diastolic mitral annular velocity...
Source: Heart and Vessels - Category: Cardiology Source Type: research
CONCLUSIONS These results indicate that GDLP against T2DM-induced hepatic steatosis, oxidative stress, and inflammation by improving the Nrf2/HO-1 signaling pathway in db/db mice, suggesting the GDLP may serve as an effective strategy for in fatty liver treatment. PMID: 32245940 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 4 April 2020Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Naresh Kumar P, Ragavendrasamy Balakrishnan, Vibhas Kana
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
Gestational diabetes mellitus (GDM) is a common complication of pregnancy associated with significant maternal and neonatal morbidities, including increased risk of pre-eclampsia, macrosomia, and subsequent type 2 diabetes.[1] In most developed countries, universal glucose testing is performed at 24-28 weeks ’ gestation to identify women with overt glucose intolerance.[2] Ideally, women at high risk of developing GDM would be identified earlier in pregnancy to facilitate preventive intervention, enhance antenatal care, and improve clinical outcomes through reduced maternal and fetal exposure to metabo lic alterations...
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
Diabetes distress (DD) leads to damaging consequences in patients with type 2 diabetes mellitus(T2DM). Few studies have been carried out on the DD among elderly in Iran. The aim of the current study was to investigate the prevalence of DD and some of its related factors on the elderly living in Qom, Iran.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
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Source: Acta Diabetologica - Category: Endocrinology Source Type: research
This study was conducted using a randomized, double-blind design and grouped subjects under two research conditions: an experimental group given Brain Breaks videos and a control group. Purposive sampling was employed to recruit 70 T2DM patients (male = 39, female = 31) with the mean age of 57.6 (SD = 8.5) from Hospital Universiti Sains Malaysia, Kelantan. Over a four-month period, the participants in the experimental group were asked to perform PA daily based on a Brain Breaks video (10 min in duration) that was shared through a WhatsApp group. All participants from both groups answered the PALMS-M questionnaire five time...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
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Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
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