MiR-BART1-5p targets core 2 β-1,6-acetylglucosaminyltransferase GCNT3 to inhibit cell proliferation and migration in EBV-associated gastric cancer.

In conclusion, both miR-BART1-5p and knockdown of GCNT3 inhibited cell proliferation and migration. In addition, EBV may regulate GCNT3 by affecting the NF-kB signaling pathway. E-cadherin, N-cadherin, vimentin, and p-ERK were found to be downstream molecules of the miR-BART1-5p/GCNT3 pathway.
PMID: 32056716 [PubMed - in process]

Source: Virology - January 31, 2020 Category: Virology Authors: Liu J, Zhang Y, Liu W, Zhang Q, Xiao H, Song H, Luo B Tags: Virology Source Type: research