Association between direct-acting oral anticoagulants vs. warfarin with the risk of osteoporosis in patients with non-valvular atrial fibrillation

Publication date: Available online 16 February 2020Source: IJC Heart &VasculatureAuthor(s): Tauseef Akhtar, Adrija Hajra, Poonam Bhyan, Raktim K. Ghosh, Dhrubajyoti Bandyopadhyay, Wilbert S. Aronow
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research

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Conclusions: DA used in primary care are effective to reduce decisional conflict and improve knowledge on the disease and treatment options, awareness of risk, and satisfaction with the decisions made. More studies are needed to assess the impact of shared decision making in primary care.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
AbstractThe incidence of osteoporosis and cardiovascular disease increases with age, and there are potentially shared mechanistic associations between the two conditions. It is therefore highly relevant to understand the cardiovascular implications of osteoporosis medications. These are presented in this narrative review. Calcium supplementation could theoretically cause atheroma formation via calcium deposition, and in one study was found to be associated with myocardial infarction, but this has not been replicated. Vitamin D supplementation has been extensively investigated for cardiac benefit, but no consistent effect h...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
CONCLUSIONS:In terms of Success, Failure and Survival rates, tissue level implants placed in Healthy and in Medically compromised individuals showed no short-term (1 year) differences.
Source: Dental Technology Blog - Category: Dentistry Source Type: news
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
CONCLUSIONS: In terms of Success, Failure and Survival rates, tissue level implants placed in Healthy and in Medically compromised individuals showed no short-term (1 year) differences. PMID: 32407061 [PubMed - as supplied by publisher]
Source: Minerva Stomatologica - Category: Dentistry Tags: Minerva Stomatol Source Type: research
CLINICAL PARAMETERS ARE MORE LIKELY TO BE ASSOCIATED WITH THYROID HORMONE LEVELS THAN WITH TSH LEVELS: A SYSTEMATIC REVIEW AND META-ANALYSIS. Thyroid. 2020 Apr 29;: Authors: Fitzgerald SP, Bean NG, Falhammar H, Tuke J Abstract BACKGROUND: Though the functional states of other endocrine systems are not defined on the basis of levels of controlling hormones, the assessment of thyroid function is based on levels of the controlling hormone thyroid stimulating hormone (TSH). We therefore addressed the question as to whether levels of thyroid hormones (free thyroxine (FT4), total triiodothyronine/free triiod...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
CONCLUSION: Despite the fact that AEs significantly increased after drug delivery, BPs are highly effective and safe for managing osteoporosis in women older than 65 years. Zoledronic acid caused an increased rate of AEs in women older than 65 years, but these AEs seemed to be mild to moderate. In addition, the hip fracture rate in women older than 80 years old treated with BPs was different than that in the other included patients. Therefore, doctors may prescribe BPs for women older than 65 years in order to increase BMD, and AEs and hip fractures in women older than 80 years should be given attention. PMID: 3232450...
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Tags: Curr Pharm Des Source Type: research
Publication date: April 2020Source: IJC Heart &Vasculature, Volume 27Author(s): Anke C. Fender, Dobromir Dobrev
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
What’s worth some 1,204.8 billion USD? Well, it’s the worldwide pharmaceutical market, of course! With such a capital at stake and with the pace of technological disruption, the pharma industry is quick to adapt to the changing times. In fact, leading drug companies are re-investing as much as 20.8% of drug sales into new drug development.  We’ve analyzed the trends shaping the future of pharma before, but how can we expect to see the landscape evolve in this new decade? With leaps in A.I., patient empowerment and 3D printed drugs, here are the 5 aspects that will be the focus of pharmaceutical co...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Pharma digital health future of medicine pharmaceutics digital health companies Source Type: blogs
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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