Association between direct-acting oral anticoagulants vs. warfarin with the risk of osteoporosis in patients with non-valvular atrial fibrillation

Publication date: Available online 16 February 2020Source: IJC Heart &VasculatureAuthor(s): Tauseef Akhtar, Adrija Hajra, Poonam Bhyan, Raktim K. Ghosh, Dhrubajyoti Bandyopadhyay, Wilbert S. Aronow
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research

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What’s worth some 1,204.8 billion USD? Well, it’s the worldwide pharmaceutical market, of course! With such a capital at stake and with the pace of technological disruption, the pharma industry is quick to adapt to the changing times. In fact, leading drug companies are re-investing as much as 20.8% of drug sales into new drug development.  We’ve analyzed the trends shaping the future of pharma before, but how can we expect to see the landscape evolve in this new decade? With leaps in A.I., patient empowerment and 3D printed drugs, here are the 5 aspects that will be the focus of pharmaceutical co...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Pharma digital health future of medicine pharmaceutics digital health companies Source Type: blogs
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Conclusion: Alendronate sodium can transiently increase the INR over 50%, induce spontaneous ecchymoses and petechiae in the skin of aged male osteoporosis patients with AF who took warfarin. Clinicians should pay enough attention when using alendronate sodium on these kinds of patients and be aware of the consequent potential bleeding risk.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Conclusion A great deal of progress is being made in the matter of treating aging: in advocacy, in funding, in the research and development. It can never be enough, and it can never be fast enough, given the enormous cost in suffering and lost lives. The longevity industry is really only just getting started in the grand scheme of things: it looks vast to those of us who followed the slow, halting progress in aging research that was the state of things a decade or two ago. But it is still tiny compared to the rest of the medical industry, and it remains the case that there is a great deal of work yet to be done at all...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
Introduction: Obstructive sleep apnea (OSA) and chronic obstructive pulmonary (COPD), are usually accompanied by several comorbidities. Aim of the study was to assess the prevalence of comorbidities in OSA and COPD-OSA overlap syndrome (OS) patients and to explore differences between these two groups.Methods: Included were consecutive OS (n=163, 138 males, AHI>5/h and FEV1/FVC5/h and FEV1/FVC>0.7), matched in terms of gender, age, BMI, and smoking history, diagnosed with polysomnography and pulmonary function testing.Results: As mentioned, the two groups were matched in age (p=0.221), BMI (p=0.496) and neck circumfer...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Sleep and control of breathing Source Type: research
Apple continues to move deeper into healthcare - particularly in the field of medical research. The tech giant has announced three health studies its U.S. customers can now enroll in through a new research app. The studies include the Apple Women’s Health Study, the Apple Heart and Movement Study, and the Apple Hearing Study. Conducted in partnership with leading academic and research institutions, these multi-year longitudinal studies are available in the new Research app, which can be downloaded today from the App Store. The Cupertino, CA-based company said now participants can potentially groundbreaki...
Source: MDDI - Category: Medical Devices Authors: Tags: R & D Source Type: news
Publication date: Available online 31 October 2019Source: The Lancet Diabetes &EndocrinologyAuthor(s): Michael R McClung, Michelle L O'Donoghue, Socrates E Papapoulos, Henry Bone, Bente Langdahl, Kenneth G Saag, Ian R Reid, Douglas P Kiel, Ilaria Cavallari, Marc P Bonaca, Stephen D Wiviott, Tobias de Villiers, Xu Ling, Kurt Lippuner, Toshitaka Nakamura, Jean-Yves Reginster, Jose Adolfo Rodriguez-Portales, Christian Roux, José Zanchetta, Cristiano A F ZerbiniSummaryBackgroundOdanacatib, a cathepsin K inhibitor, reduces bone resorption while maintaining bone formation. Previous work has shown that odanacatib incre...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research
We describe a 65-year-old man who presented with arthralgia, reduced body hair and gynecomastia. He showed severe pancytopaenia. Laboratory examination revealed high follicle-stimulating hormone, low testosterone and oestradiol, elevated antinuclear antibodies, anti-dsDNA and ESR levels, as well as low complement levels. An electrocardiogram showed atrial fibrillation. Computed tomography and dual-energy x-ray absorptiometry showed pleural effusion and osteoporosis. Chromosome analysis revealed 47, XXY karyotype. The unifying diagnosis was therefore Klinefelter's syndrome (KS) with systemic lupus erythematosus (SLE), with ...
Source: Lupus - Category: Rheumatology Authors: Tags: Lupus Source Type: research
This study investigated the association between atrial conduction time and prolidase activity, a collagen synthesis enzyme, and P-wave dispersion (PWD) in patients with paroxysmal atrial fibrillation (PAF). METHODS: Exclusion criteria included age of
Source: Combinatorial Chemistry and High Throughput Screening - Category: Chemistry Authors: Tags: Comb Chem High Throughput Screen Source Type: research
AbstractPurposeTo investigate inpatient prevalence, expenditures, and comorbidities of hospitalized patients with sarcoidosis in the USA.MethodsPatients with sarcoidosis were identified within the Nationwide Inpatient Sample (NIS) database for the years 2013 and 2014 using the respective ICD-9 diagnostic code. Data on patient and hospital characteristics, comorbidities, total hospital costs, and total hospitalization charges were collected. A propensity-matched cohort of patients without sarcoidosis from the same database was created and used as comparators for the analysis of comorbidities.ResultsA cohort of 78,055 patien...
Source: Lung - Category: Respiratory Medicine Source Type: research
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