Novel anti-Wolbachia drugs, a new approach in the treatment and prevention of veterinary filariasis?

We present the current portfolio of next-generation anti-Wolbachia candidates discovered through phenotypic screening of chemical libraries and validated in a range of in vitro and in vivo filarial infection models. Several novel chemotypes have been identified with selected narrow-spectrum anti-Wolbachia specificity and superior time-to-kill kinetics compared with doxycycline. We discuss the opportunities of developing these novel anti-Wolbachia agents as either cures, adjunct therapies or new preventatives for the treatment of veterinary filariasis.
Source: Veterinary Parasitology - Category: Veterinary Research Source Type: research

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ConclusionsTo our knowledge, this represents the first application of IVIS to the study of a human filarial parasite. This method should prove useful in studies of tissue tropism and as an efficientin vivo assay for candidate anti-filarial drugs.
Source: PLoS Neglected Tropical Diseases - Category: Tropical Medicine Authors: Source Type: research
As new lymphatic filariasis infections are eliminated through mass chemotherapy, previously affected individuals are left with the sequellae, especially chronic progressive lymphoedema. Currently this is manag...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Study Protocol Source Type: research
Prevalence of lymphatic filariasis (LF) antigen in American Samoa was 16.5% in 1999. Seven rounds of mass drug administration (MDA) programmes between 2000 and 2006 reduced antigen prevalence to 2.3%. The most...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
Publication date: Available online 10 March 2020Source: International Journal for Parasitology: Parasites and WildlifeAuthor(s): F.D. Sanchez-Godoy, A. Juarez-Murguia, R. Hernandez-Castro, J. Xicohtencatl-Cortes, F. Martinez-Hernandez, X. Hernandez-Velasco
Source: International Journal for Parasitology: Parasites and Wildlife - Category: Parasitology Source Type: research
ConclusionsAlthough uncommon, these urological infections are associated with significant morbidity and mortality and awareness in all healthcare settings is now an essential requirement.
Source: World Journal of Urology - Category: Urology & Nephrology Source Type: research
CONCLUSION: In the present study, we endeavoured to establish the extent of cross-reactivity of antigens derived from animal filarial parasites such as B. malayi and S. cervi with W. bancrofti filariasis sera of human patients. Besides, we further analyzed antibody-isotype profile of IgG, IgG4 and IgM in various human infection sera of bancroftian filarial subjects reactive to heterologous parasite antigens derived from adult worms of S. cervi from bovine and B. malayi. PMID: 32096736 [PubMed - as supplied by publisher]
Source: Protein and Peptide Letters - Category: Biochemistry Authors: Tags: Protein Pept Lett Source Type: research
Answer toParasite Case of the Week 580:Loa loamicrofilariae. As noted by several readers, the nuclei go to the tip of the tail, the microfilariae are relatively large, and there is faint evidence of a sheath, all of which are characteristic features for this species. As I teach my students, the nuclei " flow-a flow-a " (to the tip) in Loa loa. Another memory trick from William Sears is that the nuclei go " lower and lower " in Loa loa. Take your pick for your favorite! Remember that the sheath will not always be seen. Size is a more definitive feature in differentiating Mansonella spp. from th...
Source: Creepy Dreadful Wonderful Parasites - Category: Parasitology Source Type: blogs
Abstract Plateau and Nasarawa states in central Nigeria were endemic for onchocerciasis. The rural populations of these two states received annual ivermectin mass drug administration (MDA) for a period of 8-26 years (1992-2017). Ivermectin combined with albendazole was given for 8-13 of these years for lymphatic filariasis (LF); the LF MDA program successfully concluded in 2012, but ivermectin MDA continued in areas known to have a baseline meso-/hyperendemic onchocerciasis. In 2017, serological and entomological assessments were undertaken to determine if MDA for onchocerciasis could be stopped in accordance with...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
The genus Onchocerca Diesing, 1841 includes species of medical importance, such as O. volvulus (Leuckart, 1893), which causes river blindness in the tropics. Recently, zoonotic onchocercosis has been reported in ...
Source: Parasites and Vectors - Category: Microbiology Authors: Tags: Research Source Type: research
(University of Pennsylvania) Thread-like parasitic worms cause millions of cases of canine heartworm each year, and more than 100 million cases of lymphatic filariasis, also known as elephantiasis, in humans. In research led by the University of Pennsylvania's Michael Povelones, ramping up the immune response of mosquitoes blocked their ability to transmit these harmful parasites.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news
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