Galcanezumab: a humanized monoclonal antibody for the prevention of migraine and cluster headache.

Galcanezumab: a humanized monoclonal antibody for the prevention of migraine and cluster headache. Drugs Today (Barc). 2020 Jan;56(1):5-19 Authors: Ossipov MH, Raffa RB, Pergolizzi JV Abstract Migraine is a common, painful and highly disabling neurological condition that has plagued mankind for millennia, but its pathophysiology remained largely obscure until recently. The clinical success of triptans for treating migraine and the discovery that calcitonin gene-related peptide (CGRP) plays a prominent role in migraine led to increased research interest into this disease. An important improvement has been the development of monoclonal antibodies, including galcanezumab, that bind to CGRP or to its receptor, preventing its activation. Subsequent clinical trials have reported that galcanezumab is safe and well tolerated, and is effective in reducing the frequency of migraine attacks in patients with episodic or chronic migraine. At the same time, increased study of the pathophysiology of cluster headache, a relatively rare condition with excruciatingly painful headache attacks (i.e., "suicide headaches"), led to the discovery that, as in migraine, CGRP plays an important role in its pathology. Clinical trials suggest that galcanezumab is safe and effective for the prevention of episodic cluster headache, and it is under study for chronic cluster headache. Galcanezumab is approved for the prevention of migraine in the U.S., the European Union, Canad...
Source: Drugs of Today - Category: Drugs & Pharmacology Tags: Drugs Today (Barc) Source Type: research

Related Links:

This double-blind placebo-controlled, fixed/flexible-dose phase 2 trial assessed the efficacy, safety, and tolerability of cariprazine vs. placebo for depressive episodes associated with bipolar I or II disorder. Primary endpoint was change in Montgomery–Åsberg Depression Rating Scale (MADRS) total scores (baseline to week 8), and secondary endpoint was mean Clinical Global Impressions-Improvement score (week 8). Patients were randomized (N = 233) 1:1:1 to placebo, ‘low-dose’ 0.25–0.5 mg/day or ‘high-dose’ 1.5–3.0 mg/day cariprazine. Adverse events...
Source: International Clinical Psychopharmacology - Category: Psychiatry Tags: Original Articles Source Type: research
Stress caused by uncertainty can be paralyzing. The information we are getting about the coronavirus seems to be changing by the hour — creating unprecedented uncertainty. There is a good reason your nerves are jangle, or you are feeling unsettled or anxious. Uncertainty is perceived as unsafe and potentially painful. Whether the situation is predictably positive or predictably negative, your brain prefers something familiar to something unfamiliar. Under stress, our brains depend on instinct rather than rational thought because the part of the brain responsible for critical thinking is busy dealing with the psycholo...
Source: Embrace Your Heart Wellness Initiative - Category: Cardiology Authors: Tags: Stress Management uncertainty Source Type: blogs
Had a patient 2.5 years ago who committed suicide on oxycodone I had prescribed. Was taking 6 5/325s of oxycodone per day for cervical and lumbar spondylosis. No history of suicidal ideation, scored 2 on the ORT, PMP always good, no early refills. Was a patient for ten years. Was getting botox for cervicogenic headache (rebound excluded) every 3 months. Seen by me (not NPs) every 3 months. UDS 1X per year and narcotic contract. Had one UDS 5 years ago that tested well below threshold of... expert witnesses?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Withdrawal symptoms after discontinuation of antidepressants are common and have long been known. Typical symptoms after dose reduction or discontinuation of antidepressants are dizziness, drowsiness, headache, flu-like symptoms, hyperarousal, imbalance, insomnia, irritability, and nausea. Rebound, relapse, or recurrence associated with the underlying mental disorder may also occur. The occurrence of obsessive-compulsive symptoms (OCS) following abrupt discontinuation of antidepressants have not yet been reported. Here we report the development of OCS (obsessional suicidal thoughts) in a patient with major depressive disor...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
Authors: Li J, Sun M, Wang X Abstract Introduction: Lacosamide has been used in epilepsy patients in the United States, Europe and Asia since it was approved by the FDA in 2008. Many patients have benefited from this drug as a new generation of sodium channel blocker. With the worldwide use of this drug, its adverse effects have gradually emerged, especially some rare adverse events.Areas covered: The present review aims to summarize the adverse effects of lacosamide reported in the literature in recent years to promote the safe clinical application of the drug.Expert opinion: In more than 10 years of experience in...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Authors: Patel P, Konala VM, Adapa S, Gayam V, Sahasranam P, Bose S, Golez CD, Naramala S Abstract Cyanide is notoriously known to the public for more than a century now as a weapon of mass destruction (Zyklon B gas - hydrogen cyanide used by Nazis), an agent for chemical warfare during World War I (hydrogen cyanide) and very infamous "Suicide Pill" used in the past by military and espionage organizations during World War II (potassium cyanide). During the modern industrial era, cyanide poisoning is commonly associated with the industrial exposure and domestic fires. But there is little awareness about po...
Source: Journal of Population Therapeutics and Clinical Pharmacology - Category: Drugs & Pharmacology Tags: J Popul Ther Clin Pharmacol Source Type: research
Is your alcohol use turning into something you are worried about? It can be hard for many people to determine whether or not they have a problem with alcohol, but chances are, you’re not happy with your current drinking habits. If you’re wondering “do I have an alcohol problem?’, keep reading for a few tell-tale signs, what is involved with treatment, and what can happen if you leave your alcohol problem untreated. Ask Yourself These Questions If you are asking yourself, “do I have an alcohol problem?”, as yourself the following questions first. If you answer yes to most or all of them,...
Source: Cliffside Malibu - Category: Addiction Authors: Tags: Alcohol Alcohol Rehab Information Alcoholism Detox Resources for Alcohol and Drugs/Opiates alcohol abuse alcohol detox alcohol treatment Source Type: blogs
 Medication for your brain – whether you’re newly diagnosed or have been in treatment for years, you may have doubts if drugs are right for you. You’re not alone. Jackie and Gabe get real about reasons people want to quit psych meds and why our brains convince us to quit despite the benefits of taking medication. They discuss consequences you may not be aware of from just stopping your meds and why you should always involve your doctors, no matter what your decision, when it comes to medication. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an a...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antidepressant Antipsychotic Medications Not Crazy Podcast Psychology Stimulants Treatment Source Type: blogs
Medication, Therapy, Hospitalization, Electroconvulsive Therapy- what are the treatment strategies for schizophrenia? How do you convince someone they need help? What if someone refuses treatment? Schizophrenic Rachel Star Withers with co-host Gabe Howard reveal different treatments they have undergone over the years with various outcomes. Guest Barbara Thompson, with the National Alliance on Mental Illness, shares support options for people with schizophrenia and their family in the community. Highlights from “Treatment Strategies for Schizophrenia” Episode [02:00] How to bring up Schizophrenia to a loved one ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Caregivers Inside Schizophrenia Mental Health and Wellness Podcast Psychiatry Psychology Treatment Electroconvulsive Therapy getting help Living With Schizophrenia Mental Disorder Mental Illness Support Group Treatment For Schizo Source Type: blogs
Youth who are taking antidepressants in the class of serotonin reuptake inhibitors (SSRIs) for anxiety or obsessive compulsive disorder (OCD) are more likely to experience side effects that cause them to discontinue the medication than those taking serotonin-norepinephrine inhibitors (SNRIs), according to a report in theJournal of the American Academy of Child and Adolescent Psychiatry.SSRIs also appear to be more commonly associated with “activation syndrome”—a cluster of symptoms including restlessness, anxiety, and agitation.Both classes of antidepressants are commonly prescribed for young people with ...
Source: Psychiatr News - Category: Psychiatry Tags: Journal of the American Academy of Adolescent Psychiatry medications for youth with anxiety and OCD selective serotonin reuptake inhibitor side effects SNRIs treatment discontinuation Source Type: research
More News: Brain | Canada Health | Clinical Trials | Depression | Drugs & Pharmacology | Genetics | Headache | Mexico Health | Migraine | Neurology | Pathology | Study | Suicide