Characterization of Skin Microbiome Profile and it's Correlation to Radiation Dermatitis

Condition:   Radiation Dermatitis Intervention:   Diagnostic Test: Collection of skin culture samples Sponsor:   AceTech Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Conditions:   Chronic Inflammatory Disease;   Angioedema;   Severe Asthma;   Lupus;   Atopic Dermatitis;   Psoriatic Arthritis;   Multiple Sclerosis;   Systemic Sclerosis Interventions:   Genetic: Biobanking with genetic analysis;   Other: SF-12 questionnaire Sponsors:   University Hospital, Lille;   FHU IMMINeNT Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The restrictions on movement and normal interaction owing to COVID-19 pose a distinct challenge to the traditional clinical trial model, as patients, investigators and clinical staff are either confined to their homes or seeking to avoid healthcare settings.    Those running clinical trials over the past weeks have had to adapt rapidly by fast-tracking digital capabilities to ensure continued delivery. With the future of existing trials hanging in the balance, some have been pivoting to remote delivery – sometimes in the space of under a week.   Speaking at eyeforpharma Virtual, a digital versio...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Healthcare companies Sanofi and Regeneron announced on Friday more encouraging results for their Dupixent product used to treat severe atopic dermatitis, often commonly known as eczema.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Asfour L, Yiu ZZN, Warren RB Abstract Introduction: Skin conditions are common and highly varied in their etiology; therefore, a diverse array of therapeutics are utilized. Drug safety studies in dermatology can be challenging as there are over 3000 diagnoses to consider. As a result, dermatologists rely on data from multiple sources including clinical trials and real-world evidence.Areas covered: In this review, we cover the main sources of safety data available, their strengths and weaknesses and how dermatologists should utilize such data. We use real-world examples of the different types of adverse eve...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
Pharos Excimer Laser, Model: EX-308 - Product Usage: The Pharos EX-308 Excimer Laser System is designed to treat the skin disorders psoriasis, vitiligo, atopic dermatitis, and leukoderma using phototherapy. The excimer laser system produces collimated 308 nm radiation, within the invisible region of the electromagnetic spectrum. The UV radiation falls within the range of ultraviolet B (UVB), which is used to treat photo-responsive skin disorders.
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
Itch in atopic dermatitis (AD) is aggravated under warm conditions. Transient receptor potential vanilloid 3 (TRPV3), a member of the thermosensitive TRP channels, is activated by innocuous heat and is abundantly expressed in keratinocytes. The potential role of TRPV3 in itch is illustrated in TRPV3 channelopathies of human and mice. However, the role of TRPV3 in heat-induced itch in AD and the underlying mechanisms are unclear. Here we showed that keratinocytes isolated from patients with AD exhibit enhanced expression and heat sensitivity with hyperactive channel function of TRPV3.
Source: Journal of Investigative Dermatology - Category: Dermatology Authors: Tags: Original Article Source Type: research
AbstractDupilumab (Dupixent®) is a fully human IgG4 monoclonal antibody against the interleukin (IL)-4  receptor α (IL-4Rα) subunit, which is shared by the type I IL-4 and the type II IL-4/IL-13 receptor complexes. By binding to and blocking this subunit, dupilumab inhibits IL-4 and IL-13, which are the major drivers of human type 2 inflammatory disease [e.g. asthma, atopic dermatitis and chronic rhinosinusitis with nasal polyps (CRSwNP)]. Dupilumab, administered subcutaneously, is the first biological therapy to be approved for the treatment of adults with inadequately controlled CRSwNP in the EU and ...
Source: Drugs - Category: Drugs & Pharmacology Source Type: research
Purpose of review The aim of the article is to critically appraise the most relevant studies in the rapidly advancing field of food allergy prevention. Recent findings Epidemiologic studies identified atopic dermatitis as a strong risk factor for food allergy, with mounting evidence for impaired skin barrier and cutaneous inflammation in the pathogenesis. Additional risk factors include a family history of atopy, the timing of allergenic food introduction into the infant's diet, dietary diversity, vitamin D, and environmental factors, such as dog ownership. Early introduction of allergenic foods (such as peanut) into ...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: PAEDIATRICS: Edited by Berthold Koletzko and Raanan Shamir Source Type: research
Conclusions The top positive and relevant allergens seen were in concordance with other reports from Australia and the rest of the world. Fragrances and medicaments are common allergens, and it is recommended that products used on anogenital skin be fragrance free. Testing patients own products is imperative.
Source: Journal of Lower Genital Tract Disease - Category: OBGYN Tags: Vulvovaginal Disease Source Type: research
Contributors : Xuehua Piao ; Ryosuke Miura ; Ryodai Shindo ; Hiroyasu NakanoSeries Type : Expression profiling by arrayOrganism : Mus musculusCellular FLICE-inhibitory protein (cFLIP) prevents the development of dermatitis by blocking TNF α-dependent apoptosis of keratinocytes. However, it is unclear whether TNFα-independent signal might also contribute to the development of dermatitis in epidermis-specific Cflar-deficient (Cflar) mice. Here we show that Cflar;Tnfrsf1a-/- mice were born at the expected Mende lian ratio, but developed severe dermatitis and succumbed soon after birth. Whil...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Mus musculus Source Type: research
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