Potential value of V-domain Ig suppressor of T-cell activation for assessing progn osis in cervical cancer and as a target for therapy.

Potential value of V-domain Ig suppressor of T-cell activation for assessing progn osis in cervical cancer and as a target for therapy. Int J Clin Exp Pathol. 2020;13(1):26-37 Authors: Kuang L, He Y Abstract V-domain Ig suppressor of T-cell activation (VISTA), which belongs to the B7 family and is expressed predominantly on hematopoetic cells, myeloid, granulocytic and T cells, can suppresses T-cell activation in vivo and vitro. The blockade of VISTA has displayed brilliant results in certain murine tumor models. But to date, little is known about the expression and impact of VISTA in human cervical cancer (CC). To fill this gap of information, we systemically investigated the expression of VISTA on tumor cells, intratumoral immune cells (ICs) and vascular endothelial cells (VECs) in a group of patients with CC by performing immunohistochemical analysis. The associations between VISTA expression and different clinicopathologic features were evaluated using Fisher's exact test, and the analysis of overall survival in different groups was performed by the construction of Kaplan-Meier models. The results indicated that high expression of VISTA on ICs or VECs was significantly related to advanced tumor stage and the lymph node metastasis (LNM) of CC. Furthermore, we performed multivariate Cox regression analysis, which showed that there was no association between VISTA expression and the 5-year overall survival rate, and LNM was the only independent predicti...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research

Related Links:

Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Publication date: August 2020Source: Biomedicine &Pharmacotherapy, Volume 128Author(s): Qingzhi Guo, Li Li, Qimei Bo, Li Chen, Li Sun, Hongtang Shi
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
.
Source: Health Psychology Review - Category: Psychiatry & Psychology Authors: Source Type: research
AbstractOver 74,000 women in the United States are diagnosed annually with endometrial or cervical cancers and experience significant treatment-related difficulties with body image, sexuality, and sexual functioning. The aims of the research were to examine relationships among body image, sexuality, and sexual functioning, and to understand women ’s views of these concepts. A novel theoretical framework encompassing these three concepts and contextual variables guided the research. A non-experimental cross-sectional pilot study was conducted with pre-menopausal women in an academic medical center who had stages I&nda...
Source: Sexuality and Disability - Category: Disability Source Type: research
High-risk human papillomavirus (HPV) infection is an essential factor for the development of cervical cancer. HPV18 is the second most common carcinogenic HPV type following HPV16, but the lineages of HPV18 ha...
Source: Virology Journal - Category: Virology Authors: Tags: Short report Source Type: research
Lysine acetylation is a post-translational modification that regulates a diversity of biological processes, including cancer development.
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
Publication date: Available online 23 May 2020Source: Practical Radiation OncologyAuthor(s): Kelly Kisling, Carlos Cardenas, Brian M. Anderson, Joy Zhang, Anuja Jhingran, Hannah Simonds, Peter Balter, Rebecca M. Howell, Kathleen Schmeler, Beth M. Beadle, Laurence Court
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 23 May 2020Source: Journal of the American Society of CytopathologyAuthor(s): Ritu Nayar, David C. Chhieng, Barbara Crothers, Teresa M. Darragh, Diane D. Davey, Carol Eisenhut, Robert Goulart, Eric C. Huang, Sana O. Tabbara
Source: Journal of the American Society of Cytopathology - Category: Cytology Source Type: research
Telemedicine and telehealth (TM/TH) are the 2 terms used interchangeably focusing on the delivery of health care services at a long distance using telecommunication technology. TM/TH has several gynecologic applications, including the well-woman visits, preventive care, preconception counseling, family planning including contraception and medical abortion, infertility workup, teleradiology, cervical cancer screening and colposcopy, mental health, and telesurgery. The goals of TM/TH are not only improving quality of health care in patients and building a virtual community of physicians but also increasing convenience, effic...
Source: Obstetrics and Gynecology Clinics - Category: OBGYN Authors: Source Type: research
More News: Cancer | Cancer & Oncology | Cervical Cancer | Pathology