Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible.

Mouse tail models of secondary lymphedema: fibrosis gradually worsens and is irreversible. Int J Clin Exp Pathol. 2020;13(1):54-64 Authors: Zhou C, Su W, Han H, Li N, Ma G, Cui L Abstract Although the mouse tail model of secondary lymphedema has been widely used in research, our knowledge regarding some of the characteristic changes in this model is lacking. Therefore, in the current study, we aimed to identify pathologic changes after surgery. Tail lymphedema was created in C57BL/6J mice by disconnecting both superficial and deep lymphatic vessels. The surgery resulted in chronic edema formation with the proliferation of subcutaneous adipose tissue, deposition of fibrotic tissue, and gradual increase in CD4+ T lymphocyte infiltration. Furthermore, dramatic expansion and an increased number of lymphatic vessels were observed postoperatively. Lymphatic reflux was established at least 8 weeks after surgery, as evidenced by staining of the scar from the surgical excision. In addition, tissue fibrosis was irreversible, although CD4+ T cell infiltration, tail swelling, and subcutaneous adipose hyperplasia were alleviated over time. We also show that necrosis could be effectively avoided by paying attention to several details in the modeling process. As animal models play a key role in exploring the pathophysiology of disease, our findings provide strong support for the study of lymphedema. The irreversibility of fibrosis suggests the importance of treating ly...
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research

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Preventing breast cancer-related lymphedema (BCRL) by preserving upper lymphatic drainage is still controversial. Our study aimed to use the axillary reverse mapping (ARM) technique in patients who underwent a...
Source: World Journal of Surgical Oncology - Category: Cancer & Oncology Authors: Tags: Research Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Pragnya Chigurupati, Rebecca Elwell, Arie Hawazie, Kirti Kabeer, Sekhar Marla, Sadaf Jafferbhoy, Soni Soumian, Sankaran Narayanan
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Pragnya Chigurupati, Arie Hawazie, Rebecca Elwell, Kirti Kabeer, Sekhar Marla, Sadaf Jafferbhoy, Soni Soumian, Sankaran Narayanan
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
ConclusionsThese data support the need for long ‐term (24 months) prospective surveillance with frequent assessments (every 3 months) at least 15 months after surgery. Statistically significant convergence of symptom cluster scores with L‐Dex unit change supports BIS as beneficial in the early identification of subclinical lymphedema.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
Resumo O linfedema é uma condição crônica que afeta negativamente a função e a qualidade de vida. Atualmente, não existe tratamento definitivo. Todavia, algumas opções foram propostas para amenizar suas consequências. Entre elas, destaca-se a terapia complexa descongestiva (TCD), que se configura como um dos principais métodos de escolha de tratamento. Esta revisão sistemática teve por objetivo avaliar a eficácia dessa técnica no tratamento de linfedemas nos membros inferiores. Os resultados revelaram que a TCD foi eficaz...
Source: Jornal Vascular Brasileiro - Category: Surgery Source Type: research
e J Abstract Lymphedema are characterized by interstitial edema leading to swelling of extremities. They can be divided into primary and secondary lymphedema. Developmental abnormalities of the lymphatic system are responsible for the primary form of lymphedema. The secondary form of lymphedema is caused by damage of the lymphatic system due to external factors. Lymphedema can rarely be observed in patients with tuberous sclerosis complex (TSC), which is a neurocutaneous syndrome caused by pathogenic variants in the genes TSC1 or TSC2. Patients with TSC usually present with neurological manifestations and the deve...
Source: Gene - Category: Genetics & Stem Cells Authors: Tags: Gene Source Type: research
This study investigated the volumetric differences between the suprafascial and subfascial compartments of patients with unilateral lower extremity lymphedema. Methods: Thirty-two female patients with unilateral lower extremity lymphedema were enrolled, with eight patients in each of Cheng lymphedema grades I to IV. The volumes of the suprafascial and subfascial compartments were calculated after manually drawing the region of interest on computed tomographic images. The volumetric differences and their ratios in the suprafascial and subfascial compartments between each patient’s bilateral limbs were compared. Re...
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Reconstructive: Lower Extremity: Original Articles Source Type: research
No abstract available
Source: Plastic and Reconstructive Surgery - Category: Cosmetic Surgery Tags: Letters Source Type: research
ConclusionsScreening and management of distress, problems, and referral wish are important, even years after chemotherapy completion as a substantial proportion of breast cancer survivors continue to report elevated distress and problems. Special attention should be paid to survivors reporting physical problems, especially fatigue and lack of physical fitness, since these problems are most strongly related to continuing elevated distress.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Conclusions: Patients with lymphedema and obesity should be viewed at high risk of developing recurrence of erysipelas and thus should be considered as candidates for antibiotic prophylaxis and other prevention methods. Minor local trauma directly preceding the skin infection does not by itself confer a higher risk for erysipelas recurrence. More research is needed to assess the association of recurrent skin and soft-tissue infection to preceding minor local trauma, individual components of the metabolic syndrome, and COPD. PMID: 32454817 [PubMed]
Source: Interdisciplinary Perspectives on Infectious Diseases - Category: Infectious Diseases Tags: Interdiscip Perspect Infect Dis Source Type: research
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