Long Noncoding RNA X-Inactive Specific Transcript (XIST) Promotes Osteogenic Differentiation of Periodontal Ligament Stem Cells by Sponging MicroRNA-214-3p.

CONCLUSIONS XIST participates in osteogenic differentiation of PDLSCs by sponging miR-214-3p. PMID: 32057034 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research

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UCLA researchers have received a $13 million grant from the National Institutes of Health to find new ways to overcome melanoma resistance to some of the most promising targeted therapies and immunotherapies.There have been significant advancements in the past decade using targeted therapies and immunotherapies for treating people withadvanced forms of this deadliest type of skin cancer, but the treatments still only work in some people. Tumors can — and oftendo— become resistant to these drugs.“While these therapies have transformed the way people with melanoma are treated, only about 40% to 50% of peopl...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Researchers here note that delivering metformin via injection rather than the usual oral administration removes unwanted side-effects and better improves cognitive function in old mice. Near all testing of metformin has used oral administration, and the effects on pace of aging and life span are, frankly, too unreliable and too small to justify the present level of interest in the drug on the part of the longevity community. Administration by injection might be a different story, but waiting on further research and confirming data would be a wiser course of action than immediate excitement. Even then, this is tinkering wit...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
(University of Cologne) An international research team has shown in mice that Rictor, a protein that helps to regulate the growth, energy, and oxygen consumption of cells, plays a key role in the cellular metabolism and longevity of hair follicle stem cells / publication in 'Cell Metabolism'
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Source: Infection and Drug Resistance - Category: Infectious Diseases Tags: Infection and Drug Resistance Source Type: research
Satellite cells are residential muscle stem cells that express a paired box transcription factor PAX7. Pax7 has been shown to be involved in determination of myogenic cell lineage during development, yet it is also required for the postnatal muscle growth, muscle regeneration and maintenance of the satellite cell pool. Although the functions of Pax7 have been studied thoroughly, its interacting partners in myogenic cells in vivo are largely unknown due to the lack of proper antibodies for immunoprecipitation.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Urine-derived stem cells (USCs) are known to be a very promising source of stem cells, in addition their isolation is non-invasive, relatively quick and simple, affordable, ubiquitous, and readily accepted by patients. The USCs transcriptional profiling showed a great variability across individuals probably due to the co-presence of distinct cell types. The lack of specific and unique cell surface markers for the identification of cell types makes the separation difficult. In order to separate the USCs sub-populations, we used the new technology Celector that sorts the cells based only on their physical characteristics.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
X-linked dilated cardiomyopathy (XLDCM) is a serious condition caused by abnormalities in the DMD gene (dystrophin gene). The affected patients did not have major skeletal weakness but presented with early signs of heart failure, and deteriorated quickly despite medical treatment resulting in early death. Currently there is no curative treatment and heart transplantation is often required. We study the pathomechanism of the DMD-associated XLDCM with mutation in the first exon-intron boundary, through examination of dystrophin isoforms expression and the functional characterization of the manifested cardiomyocytes generated...
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Efficient cell migration requires cellular polarization, which is characterized by the formation of leading and trailing edges, appropriate positioning of the nucleus and reorientation of the Golgi apparatus and centrosomes towards the leading edge. Migration also requires the development of an asymmetrical front-to-rear calcium gradient to regulate focal adhesion assembly and actomyosin contractility. Here we demonstrate that silencing of syndecan-4, a transmembrane heparan sulfate proteoglycan, interferes with the correct polarization of migrating mammalian myoblasts (i.e., activated satellite stem cells).
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
Duchenne muscular dystrophy (DMD) is caused by mutations in the dystrophin gene. Although DMD is a progressive degenerative disease, there is evidence for early, embryonic-stage defects in myogenesis and gene expression in DMD. By understanding how these defects initiate and contribute to DMD pathology, we may be better positioned to identify and utilize DMD therapies. Using single-cell RNAseq, we have identified one of the earliest known DMD phenotypes: a novel transcriptional trajectory of DMD human induced pluripotent stem cells (hiPSCs) undergoing myogenesis.
Source: Neuromuscular Disorders - Category: Neurology Authors: Source Type: research
ara Numerous findings have indicated that CSCs, which are present at a low frequency inside primary tumors, are the main cause of therapy resistance and cancer recurrence. Although various therapeutic methods targeting CSCs have been attempted for eliminating cancer cells completely, the complicated characteristics of CSCs have hampered such attempts. In analyzing the biological properties of CSCs, it was revealed that CSCs have a peculiar metabolism that is distinct from non-CSCs to maintain their stemness properties. The CSC metabolism involves not only the catabolic and anabolic pathways, but also intracellular sign...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
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