Identification of Hub Genes and Pathways in Gastric Adenocarcinoma Based on Bioinformatics Analysis.
CONCLUSIONS This research distinguished hub genes and relevant signal pathways, which contributes to our understanding of the molecular mechanisms, and could be used as diagnostic indicators and therapeutic biomarkers for gastric adenocarcinoma. PMID: 32058995 [PubMed - in process]
Conclusion: The long-term prognosis appears equivalent t in patients with endoscopic resection and gastrectomy.
Rationale: Signet ring cell carcinoma of the stomach is prone to relapse and metastasis after traditional surgical treatment, and the prognosis is also poor. We improved the concept of treatment and conducted cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) combined with intraperitoneal (IP) and intravenous (IV) chemotherapy for a gastric signet-cell carcinoma patient. Patient concerns: A 65-year-old male patient with complaint of intermittent hematemesis for over 10 days was referred to our hospital for treatment. The patient developed hematemesis of 800 mL without obvious causes o...
CONCLUSIONS: The occurrence of squamous hyperplasia, adenomatous hyperplasia and adenocarcinoma increased after gastrojejunal anastomoses, which cause duodenogastric reflux. The association of omeprazole did not protect the development of proliferative lesions and cancer induced by duodenogastric reflux in rats. PMID: 33027361 [PubMed - as supplied by publisher]
The majority of endocervical adenocarcinomas (EAs) are caused by human papillomavirus (HPV). Gastric-type EA, the second most common EA and unrelated to HPV, is biologically different with a more aggressive clinical course. Our knowledge of the molecular fingerprint of these important EA types and its role in diagnosis, prognosis and management is still evolving. Thus, we sought to evaluate the genomic profile of HPV-related and gastric EA. Clinical information including patient outcome was gathered for 56 tumors (45 HPV-associated and 11 gastric-type) surveying evaluated by a targeted massively parallel sequencing assay (...
ConclusionsIntraoperative molecular imaging of gastric adenocarcinoma with OTL38 is feasible. Further studies should evaluate the clinical utility of this technique.
In this study, we found a high correlation between macrophage infiltration and PD-L1 expression in gastric cancer (GC) specimens. Further study revealed that infiltrated macrophages released the proinflammatory cytokines TNF-ɑ and IL-6, which induced PD-L1 expression in tumor cells. The release of TNF-ɑ and IL-6 activated the NF-kB and STAT3 signaling pathway to regulate PD-L1 expression. TNF-α, p-65 and STAT3 expression in cancer patients has prognostic value in stomach adenocarcinoma. Furthermore, infiltrated macrophages can also promote GC cell proliferation by inducing PD-L1 expression in GC cells. Taken togeth...
Condition: Locally Advanced or Metastatic Gastric Adenocarcinoma Interventions: Drug: Camrelizumab; Drug: Apatinib Mesylate; Drug: nab-paclitaxel Sponsor: The First Affiliated Hospital of Xiamen University Recruiting
This case report details off-label treatment of a patient ’s gastric adenocarcinoma with erdafitinab.
Gastric adenocarcinoma (GA) has a poor 5-year survival of only 31.5%, partly due to ineffective chemotherapy options. The TNF-related apoptosis-inducing ligand (TRAIL) pathway leads to cell death by binding the death receptor 5 (DR5), inducing apoptosis. ONC201 is a small molecule that activates the TRAIL pathway via the integrated stress response, and has been shown to induce cell death in numerous tumor types. We investigated the ability of ONC201 to induce cell death in GA as monotherapy and in combination with recombinant human TRAIL (rhTRAIL).
Neoadjuvant chemotherapy (NAC) and chemoradiotherapy (NACR) have become increasingly common for pancreatic adenocarcinoma (PDAC) and ampullary cancers, but data regarding associated postoperative complications is mixed.