Adherence to the mediastinal staging guideline and unforeseen N2 disease in patients with resectable non-small cell lung cancer: Nationwide results from the Dutch Lung Cancer Audit - Surgery

Centrally located primary lung tumour defined as visibility of the tumor on video bronchoscopy in the main stem, lobair or segment bronchi or tumor adherent to or in between segment bronchi or blood vessels on computed tomography. (DLCA-S definition)
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research

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We report a case of concomitant metastasis in the nasal tip and suspected buttocks metastasis secondary to lung cancer, who complained of repeated cough and white sputum for 6 months. Diagnose: Primary lung cancer was diagnosed by bronchoscopy and biopsy, lesion on nasal tip was confirmed by biopsy. Furthermore, PET-CT scan identified the untouchable buttocks lesion that could have been easily missed. Interventions: This patient refused systemic treatments, but he chose traditional Chinese medicine at home. Outcomes: He died 6 months after the diagnosis. Lessons: The possibility of metastasis of primary cancers...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Publication date: Available online 12 August 2019Source: Respiratory Medicine Case ReportsAuthor(s): Daisuke Himeji, Gen-ichi Tanaka, Chikara Fukuyama, Atsushi Yamanaka, Ritsuya Shiiba, Sayaka Moriguchi, Kousuke MarutsukaAbstractA 70-year-old woman diagnosed with advanced, non-resectable programmed cell death ligand 1-positive-non-small-cell lung carcinoma was treated with pembrolizumab as first-line therapy. Soon after therapy initiation, she presented with severe dyspnea, and chest computed tomography revealed a soft tissue mass in the lower trachea of the right main bronchus. During bronchoscopy, she became severely hyp...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
Guidelines recommend endosonography for mediastinal nodal staging in patients with resectable nonsmall cell lung cancer (NSCLC). We hypothesise that a systematic endobronchial ultrasound (EBUS) evaluation combined with an oesophageal investigation using the same EBUS bronchoscope (EUS-B) improves mediastinal nodal staging versus the current practice of targeted positron emission tomography (PET)-computed tomography (CT)-guided EBUS staging alone. A prospective, multicentre, international study (NCT02014324) was conducted in consecutive patients with (suspected) resectable NSCLC. After PET-CT, patients underwent systematic ...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Lung cancer Original Articles: Lung cancer Source Type: research
The optimal approach to follow patients up after surgical resection of non-small cell lung cancer (NSCLC) is keenly debated; including what imaging modality to use and the intensity of clinical assessments. A systematic review in 2012 concluded that “the paucity of evidence precludes firm evidence based guidelines” [1]. This uncertainty leads to a variability of practice nationally and internationally, which ranges from routine physical examination plus chest X-ray (CXR) [2] to more intensive protocols including routine computed tomography (CT) of the thorax, bronchoscopy, abdominal ultrasound, CT brain and bon...
Source: Lung Cancer - Category: Cancer & Oncology Authors: Source Type: research
Conclusion The position of the staple placed on the interlobar fissure should be evaluated using computed tomography in postoperative middle lobe atelectasis. If the aeration maneuver for middle lobe atelectasis using bronchoscope fails, rethoracotomy should be considered.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We report a first case of a patient experiencing reactivation of pulmonary tuberculosis (TB) during treatment of oral tyrosine kinase inhibitor (TKI) with non-small cell lung cancer (NSCLC). A 44-year-old male patient visited the hospital with cough. He had been treated with erlotinib (oral TKI) for 8 months after being diagnosed as NSCLC with sensitive epidermal growth factor receptor mutation in our clinic. At initial chest imaging, the patient had fibroatelectatic calcified granuloma in the right upper lobe (RUL) apex as well as 1.9 cm × 2.5 cm sized cancer mass encasing the RUL bronchus. He had not been treated f...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Authors: Rotolo N, Imperatori A, Nosotti M, Santambrogio L, Palleschi A, Dominioni L, Crosta G, Foccoli P, Pariscenti G, Passera E, Bortolotti L, Falezza G, Infante M, Daffrè E, Cattoni M, Rosso L Abstract BACKGROUND: Multi-institutional studies of endobronchial-ultrasound transbronchial needle aspiration (EBUS-TBNA) for mediastinal staging in lung cancer are scarce. It is unclear if the high diagnostic performance of EBUS-TBNA reported by experts' guidelines can be generally achieved. METHODS: This is a retrospective study performed in five tertiary referral centers of thoracic surgery in Italy, to asse...
Source: Journal of Thoracic Disease - Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Conclusion: Bronchoscopy allows for a dynamic lung cancer tissue response evaluation and might have an impact in further therapeutic decisions.
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: 11.1 Lung Cancer Source Type: research
The Oncology Grand Rounds series is designed to place original reports published in the Journal into clinical context. A case presentation is followed by a description of diagnostic and management challenges, a review of the relevant literature, and a summary of the authors’ suggested management approaches. The goal of this series is to help readers better understand how to apply the results of key studies, including those published in Journal of Clinical Oncology, to patients seen in their own clinical practice. A 54-year-old man with a former 15-pack-year smoking history presents with cough and dyspnea. Initial wor...
Source: Journal of Clinical Oncology - Category: Cancer & Oncology Authors: Tags: Oncology Grand Rounds Source Type: research
In conclusion, the case was presented because of extremely rare occurence of NSCLC secreting β-HCG. PMID: 27266288 [PubMed - as supplied by publisher]
Source: Tuberkuloz ve Toraks - Category: Respiratory Medicine Authors: Tags: Tuberk Toraks Source Type: research
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