Dosage Schedule Linked to Rate of PCV Breakthrough Infections Dosage Schedule Linked to Rate of PCV Breakthrough Infections
A dosing schedule that includes three primary doses of pneumococcal conjugate vaccine (PCV) is associated with fewer breakthrough infections in the first year of life than are schedules with two primary doses, according to a new study of surveillance data.Reuters Health Information
SAD is frequently associated with chronic and recurrent rhinosinusitis (CRS) and is defined as inadequate post-vaccination percentage of protective ( ≥1.3 ug/mL) pneumococcal antibody serotypes /total tested serotypes (post-pPA). Although
SAD is common among patients with recurrent respiratory infections and is defined by the degree of inadequate response to polysaccharide pneumococcal vaccines.
Several primary immunodeficiencies (PIDs) are related poor responses of polysaccharide antibodies, such as variable common immunodeficiency (CVID), selective IgA deficiency, IgG subclass deficiency, and specific antibody deficiency (SAD). The aim of this study was to describe the clinical characteristics patients with poor polysaccharide antibody response
Priming with pneumococcal conjugate PCV13 vaccine elicits T-cell dependent durable immune responses. We sought to explore whether administering PCV13 prior to PPSV23 leads to higher, more durable pneumococcal responses in asthmatic adults.
What do the new PCV13 recommendations mean, and how do you implement them in your practice? Here's what you need to know.CDC Expert Commentary
Review recent changes in ACIP's recommendations for pneumococcal conjugate vaccine use in older adults.Morbidity &Mortality Weekly Report
ConclusionThe lack of evidence-based gold standards for the diagnosis of SAD represents a challenge in clinical practice. In our cohort, we confirmed the insufficient correlation between different methods of specific PPV response measurement, and showed that theS. typhi Vi response was not contributive. Caution in the interpretation of results is warranted until more reliable diagnostic methods can be validated.
64 year old male with polymyositis previously treated with rituximab 5 years prior presented with hypogammaglobulinemia. Polymyositis was poorly controlled and the patient needed clearance prior to restarting rituximab. The patient had no significant infection history. Screening laboratories included a low IgG of 610, low IgM of 31 and protection to 4/14 post vaccination pneumococcal titers.
Vaccine knowledge and anticipated rates of vaccination even lower for pneumococcal disease
Abstract Acute otitis media (AOM) is the most common diagnosis in childhood acute sick visits. By three years of age, 50% to 85% of children will have at least one episode of AOM. Symptoms may include ear pain (rubbing, tugging, or holding the ear may be a sign of pain), fever, irritability, otorrhea, anorexia, and sometimes vomiting or lethargy. AOM is diagnosed in symptomatic children with moderate to severe bulging of the tympanic membrane or new-onset otorrhea not caused by acute otitis externa, and in children with mild bulging and either recent-onset ear pain (less than 48 hours) or intense erythema of the t...