Lateralization of increased density of Iba1-immunopositive microglial cells in the anterior midcingulate cortex of schizophrenia and bipolar disorder

AbstractThere is increasing evidence from genetic, biochemical, pharmacological, neuroimaging and post-mortem studies that immunological dysregulation plays a crucial role in the pathogenesis of psychoses. The involvement of microglia in schizophrenia and bipolar disorder (BD) has remained controversial, however, since results from various post-mortem studies are still inconclusive. Here, we analyzed the estimated density of microglia of age-matched individuals with schizophrenia (n = 17), BD (n = 13), and non-psychiatric control subjects (n = 17) in the anterior midcingulate cortex (aMCC), a brain area putatively involved in the pathogenesis of psychoses, using ionized calcium binding adaptor molecule 1 (Iba1)—immunohistochemistry. The microglial cells displayed a homogenously distributed Iba1—staining pattern in the aMCC with slightly varying activation states in all three groups. The estimated microglial densities did not differ significantly between individuals with schizophrenia, BD and control subjects. Remarkably, when both hemispheres were investigated separately within the three groups, the density was significan tly lateralized towards the right aMCC in schizophrenia (p = 0.01) and—even more evident—in BD subjects (p = 0.008). This left–right lateralization was not observed in the control group (p = 0.52). Of note, microglial density was significantly lo...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research

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(MediaSource) A multistate study of Medicaid enrollees led by researchers at The Ohio State University Wexner Medical Center found that suicide risk was highest among youth with epilepsy, depression, schizophrenia, substance use and bipolar disorder. In addition, the odds of suicide decreased among those who had more mental health visits within the 30 days before the date of suicide.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Men and women experience schizophrenia differently; from the age of onset to symptoms and how society treats those with mental disorders.  Schizophrenic, Rachel Star Withers and co-host Gabe Howard continue the discussion of the differences from the last episode but change the focus to men.  Jason Jepson, an author who has schizophrenia joins for a man’s perspective and Dr. Hayden Finch returns to explain the clinical side of the issues. Highlights in “Schizophrenia in Men” Episode [01:30] Age of onset [04:00] Symptoms in men vs women [05:00] Interview with Jason Jepson [07:30] Jason discusses ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Inside Schizophrenia Men's Issues Psychiatry Psychology Living With Schizophrenia Mental Disorder Mental Health Mental Illness Symptoms Of Schizophrenia Source Type: blogs
  Are people with mental illness more creative? Jackie believes there may be a link between the two, while Gabe thinks it’s just a bunch of hoopla. Get ready — they’ve both done their research and are ready to back their claims. Tune in to hear a lively (and friendly) debate on whether the science is valid, the difference between inspiration and creativity, as well as their own opinions and experiences on mental illness and creativity. What’s your take? Join us on this Not Crazy podcast to see whose side you’re on, or if you’re somewhere in the middle. (Transcript Available Belo...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Bipolar Creativity Disorders General Mental Health and Wellness Not Crazy Podcast Schizophrenia Source Type: blogs
Less than half of individuals who were seen in an emergency department (ED) in Ontario for a mental health –related issue had a follow-up visit with a physician within two weeks after discharge, according to astudy published today inPsychiatric Services in Advance. Those who had a substance use disorder were even less likely to have a follow-up visit with a physician during this period compared with those who did not have a substance use disorder, the study found.“Whether individuals present voluntarily because of subjective distress or involuntarily (for example, with police escort) because of acute risk, psyc...
Source: Psychiatr News - Category: Psychiatry Tags: bipolar disorder emergency department follow-up visit Lucy Barker Ontario Psychiatric Services in Advance schizophrenia serious mental illness substance use disorders Source Type: research
BACKGROUND: We compared male and female American veterans with schizophrenia or bipolar disorder regarding clinical characteristics associated with lifetime suicidal ideation and behavior. Subsequent mortality, including death by suicide, was also assessed...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
Authors: Petrasch-Parwez E, Schöbel A, Benali A, Moinfar Z, Förster E, Brüne M, Juckel G Abstract There is increasing evidence from genetic, biochemical, pharmacological, neuroimaging and post-mortem studies that immunological dysregulation plays a crucial role in the pathogenesis of psychoses. The involvement of microglia in schizophrenia and bipolar disorder (BD) has remained controversial, however, since results from various post-mortem studies are still inconclusive. Here, we analyzed the estimated density of microglia of age-matched individuals with schizophrenia (n = 17), BD (n&th...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Psychiatry Tags: Eur Arch Psychiatry Clin Neurosci Source Type: research
Over this past weekend, I participated in my first outreach event for Mental Health America at the NBC4 Telemundo 44 Health and Fitness Expo in Washington, D.C.  Dr. Martin Luther King said that people “fear each other because they do not know each other.  They do not know each other because they do not communicate with each other.”  Here is what I learned at the event: it is easy to communicate with people about mental health because the topic is accessible across culture, race and age. In addition, talking about mental health is especially important to those with mental illness. We had a s...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Communication Conferences General Mental Health America Mental Health and Wellness Policy and Advocacy Publishers connection Mental Health Advocacy Mental Health Policy Source Type: blogs
  Rich celebrity on TV: “Have you ever been sad? You might have depression.” If scenarios like this make you want to throw a rock at a window, you aren’t alone. In today’s episode, Gabe expresses his distaste for celebrities posing as the “face” of mental illness. He feels further validated after watching a satirical episode of BoJack Horseman, in which Mr. Peanutbutter, a cheerful canine celebrity, becomes the new face of depression — first as a “sad dog” meme and then as a depression spokesperson. What do you think? Tune in to hear Jackie and Gabe get into a ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Celebrities Depression Disorders General Mental Health and Wellness Not Crazy Podcast Source Type: blogs
Comorbidity is the presence of one or more additional conditions co-occurring with a primary condition. In this episode, host schizophrenic Rachel Star Withers with her cohost Gabe Howard will be discussing comorbidity with schizophrenia. Comorbidity is associated with worse health outcomes, more complex clinical management and increased health care costs. Occupational therapist and host of the podcast Occupied, Brock Cook, will be joining us to discuss ways that he works with people with schizophrenia to manage multiple health issues.  Highlights from “Comorbidity with Schizophrenia” Episode [01:28] What ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antipsychotic Inside Schizophrenia Mental Health and Wellness Psychiatry Psychology Psychotherapy Bipolar disorder and schizophrenia comorbid comorbid psychiatric conditions Comorbidities Comorbidity Diagnosis Of Schizophrenia Livi Source Type: blogs
Maurizio Pompili Psychological pain is a core clinical factor for understanding suicide, independently from depression. The aim of this study is to assess the role of psychological pain on suicide risk and to evaluate the relationship between psychache and different psychiatric disorders. We conducted the present cross-sectional study on 291 inpatients with a diagnosis of major depressive disorder, bipolar disorder, and schizophrenia. We administered Shneidman’s Psychological Pain Assessment Scale (PPAS) for the assessment of mental pain and the Mini International Neuropsychiatric Interview (MINI) for the as...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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