Two-dimensional speckle tracking echocardiography in goats: repeatability, variability, and validation of the technique using an exercise test and an experimentally induced acute ischemic cardiomyopathy

Two-dimensional speckle tracking (2DST) technique has been validated in numerous animal species, but neither studies of repeatability nor measurements after exercise or in animals with cardiac disease have bee...
Source: BMC Veterinary Research - Category: Veterinary Research Authors: Tags: Research article Source Type: research

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AbstractTafamidis, a non ‐nonsteroidal anti‐inflammatory benzoxazole derivative, acts as a transthyretin (TTR) stabilizer to slow progression of TTR amyloidosis (ATTR). Tafamidis meglumine, available as 20‐mg capsules, is approved in more than 40 countries worldwide for the treatment of adults with early‐stage sympt omatic ATTR polyneuropathy. This agent, administered as an 80‐mg, once‐daily dose (4 × 20‐mg capsules), is approved in the United States, Japan, Canada, and Brazil for the treatment of hereditary and wild‐type ATTR cardiomyopathy in adults. An alternative single solid oral dosage formulati...
Source: Clinical Pharmacology in Drug Development - Category: Drugs & Pharmacology Authors: Tags: Original Manuscript Source Type: research
AbstractA 4-year-old boy with Noonan syndrome accompanied by hypertrophic obstructive cardiomyopathy presented with refractory heart failure owing to severe left ventricular outflow obstruction and mitral regurgitation. He underwent mitral valve replacement and trans-mitral myectomy. The pathology of the resected myocardium was consistent with hypertrophic cardiomyopathy, and the mitral valve leaflets were severely degenerated. Compared with a control patient who is a non-syndromic 4-year-old boy with hypertrophic obstructive cardiomyopathy, mitral pathology was much more severe in Noonan syndrome. Regarding trans-mitral m...
Source: General Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Publication date: March–April 2020Source: Heart &Lung, Volume 49, Issue 2Author(s): John Berk, Thibaud Damy, Brian Drachman, Perry Elliott, Stephen Gottlieb, Martha Grogan, Balarama Gundapaneni, Mazen Hanna, James Hoffman, Scott Hummel, Daniel Judge, Daniel Lenihan, Giampaolo Merlini, Terrell Patterson, Claudio Rapezzi, Jeffrey Schwartz, Sanjiv Shah, Marla Sultan, Eric Velazquez, Márcia Waddington Cruz
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: March–April 2020Source: Heart &Lung, Volume 49, Issue 2Author(s): Spencer Guthrie
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: March–April 2020Source: Heart &Lung, Volume 49, Issue 2Author(s): Ladene Case, Julie Deibert, Orvar Jonsson, Stephanie Preister
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research
Publication date: Available online 28 March 2020Source: Journal of Cardiology CasesAuthor(s): Hiroaki Yamamoto, Chieko Itamoto, Minato Hayashi, Tsunesuke Kohno, Yu Matsumura, Minako Hayakawa, Fumitaka Yamaki
Source: Journal of Cardiology Cases - Category: Cardiology Source Type: research
Frequent premature ventricular complexes (PVCs) can result in cardiomyopathy, may be reversible with appropriate PVC suppression.1 Likewise, some type of PVCs are associated with an increased risk of sudden cardiac death (SCD).1 PVCs have been considered benign and treated conservatively in a significant percentage of patients because the fundamental pathogenesis of PVC-induced cardiomyopathy remains ill-defined. Several analyses of patients referred for catheter ablation have identified different PVC characteristics as independent risk factors for cardiomyopathy including but not limited to PVC burden, PVC origin and coup...
Source: Heart Rhythm - Category: Cardiology Authors: Source Type: research
Written by Pendell Meyers, case submitted by Tom FieroA man in his 30s walked into the ED complaining of chest pain. His triage ECG was done at 11:30 (no prior was available):What do you think?Sinus tachycardiaNormal QRS complex pattern, with borderline low voltageVery slight STE in leads V2-V5Proportionally large and fat T-waves in V4-5 with straightening of the ST segmentsT-waves also concerning in II, III, aVF, with inappropriately negative T-waves in aVLUsing the LAD OMI vs. BER formula:3 Variable: 27.34 (positive for OMI, using STE60V3=1.5mm, QTc=444, RWV4=2.0mm)4 Variable: 23.01 (positive for OMI, using QRS amplitude...
Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
CONCLUSION: MiR-144 regulates proliferation and apoptosis of HG-induced AC16 cardiomyocytes through targeting the CTRP3/JNK signaling pathway, providing a novel avenue for treatment of DCM. PMID: 32211094 [PubMed]
Source: International Journal of Clinical and Experimental Pathology - Category: Pathology Authors: Tags: Int J Clin Exp Pathol Source Type: research
Abstract Takotsubo syndrome (TTS), also known as stress cardiomyopathy, is a type of acute heart failure syndrome triggered by intense psychological or physiological stress. TTS typically manifests as acute chest pain, dyspnea or syncope that mimics an acute myocardial infarction but does not involve coronary artery obstruction. The current understanding of the pathogenesis of TTS suggests that sympathetic nervous system (SNS) activation plays a central role. Specifically, stress can activate the SNS and lead to the over-release of catecholamine, which have toxic effects on myocardial tissue when present at excess...
Source: Cardiology Research and Practice - Category: Cardiology Authors: Tags: Cardiol Res Pract Source Type: research
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