Nonindependence of patient data in the clinical practice research datalink: a case study in atrial fibrillation patients.
Conclusion: While strategies which longitudinally append patient registration periods under different CPRD IDs maintain independence while using all available data, their implementation had little impact on the results of our case study. PMID: 32056446 [PubMed - as supplied by publisher]
Contributors : David Milan ; Ling XiaoSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusThe aim of this study is to perform transcriptome analysis on mouse left atrium tissue after long-term ibrutinib treatment or cardiac CSK knockout, in order to compared the enriched gene clusters.
Atrial fibrillation (AF) is common in patients with the left ventricular assist device (LVAD), but the little is known about the impact of AF on clinical outcomes. The aim of this study is to investigate the impact of AF on outcomes in patients with the HeartMate 3 (HM3) LVAD.
Falls and syncope are associated with increasing age and cause considerable morbidity and mortality in the elderly.1 Beyond age, traditionally recognized risk factors for falls include unsteady gait, muscle weakness, impaired cognition, and polypharmacy. Malik et al2 present a detailed systematic review evaluating the role of atrial fibrillation (AF) in falls/syncope and conclude that AF is independently associated with falls (odds ratio [OR], 1.19; 95% CI, 1.07-1.33) and syncope (OR, 1.88; 95% CI, 1.20-2.94) based on a meta-analysis of 7 and 3 observation al studies, respectively.
There is paucity of information on clinical characteristics and outcome of patients with familial atrial fibrillation (AF). The present study was aimed to compare clinical profile and outcome of familial AF with those of non-familial AF.
In patients with severe aortic stenosis (AS), atrial fibrillation (AF) is associated with increased long-term mortality after aortic valve replacement (AVR), which may be due to unfavorable hemodynamics in AF. We aimed to analyze the hemodynamic profile of patients with severe AS and AF versus sinus rhythm (SR).
To examine the potential association of atrial fibrillation (AF) to syncope and falls, we undertook a systematic review and meta-analysis given the increasing prevalence of AF in older adults as well as emerging data that it is a risk factor for dementia.
The purpose of this study was to evaluate the effectiveness of topical amiodarone applied to the atria and pulmonary veins at the time of lung transplantation (LTx) in decreasing postoperative atrial fibrillation (POAF).
The left atrium (LA) in heart transplant (HT) recipients is a surgically created chamber from variable portions of donor and recipient. In the non-HT patients there is strong evidence that left atrial volume (LAV) is a robust predictor of cardiovascular outcomes such as atrial fibrillation, stroke, heart failure and cardiovascular death. Thus, we thought to 1) characterize LA size in HT recipients and 2) investigate the implications of “new” LA volume on HT outcomes.
ConclusionsStroke or stroke-like syndrome of infectious origin can be observed in an important proportion of case presenting with sensory-motor deficit of unknown origin; their accurate diagnosis has a considerable impact in terms of treatment choices and outcome.
This study deals with the clinical, echocardiographic, and prognostic outcomes in these patients. Prognostic scores, as MAGGIC (Meta-analysis Global Group in Chronic Heart Failure) score, may help to predict the outcomes.MethodsFrom a single center, 47 patients with AF, HF, and left ventricular ejection fraction (LVEF)