Restoration of MARCK enhances chemosensitivity in cancer.

CONCLUSIONS: Cells devoid of MARCKS function showed incomplete ABCB1 internalization, leading to higher ABCB1 activity enhancing chemoresistance. Vice versa our data suggest the prevention of MARCKS inhibition by reversing hyperphosphorylation or genomic restoration after deletion as two promising approaches to overcome tumor cell resistance towards chemotherapeutic ABCB1 substrates. PMID: 32056006 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32056006?dopt=Abstract

Source: Clinical Colorectal Cancer - February 12, 2020 Category: Cancer & Oncology Authors: Wenzel T, Büch T, Urban N, Weirauch U, Schierle K, Aigner A, Schaefer M, Kalwa H Tags: J Cancer Res Clin Oncol Source Type: research