Lilly and Roche antiamyloid drugs fail in trial of early-onset Alzheimer's trial

Source: Chemical and Engineering News - Category: Chemistry Authors: Source Type: research

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To elucidate the key molecules, functions, and pathways that bridge mild cognitive impairment (MCI) and Alzheimer's disease (AD), we investigated open gene expression data sets. Differential gene expression profiles were analyzed and combined with potential MCI- and AD-related gene expression profiles in public databases. Then, weighted gene co-expression network analysis was performed to identify the gene co-expression modules. One module was significantly negatively associated with MCI samples, in which gene ontology function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment analysis showed that these genes ...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
ConclusionsStroke volumes, reversed-flow rates, and shear stress through the cerebral aqueduct on 4D flow MRI are useful parameters for iNPH diagnosis. These findings can aid in elucidating the mechanism of ventricular enlargement in iNPH.Key Points• The CSF stroke volume and bimodal shear stress at the cerebral aqueduct were considerably higher in patients with iNPH.• The patients with pure iNPH had significantly higher shear stress at the ventral aspect of the cerebral aqueduct than those with co-occurrence of iNPH and AD.• The shear stress at the cerebral aqueduct was significantly associated with the dia...
Source: European Radiology - Category: Radiology Source Type: research
CONCLUSIONS: Our study results corroborate earlier findings that the CSF tool is of added value to the diagnostic workup in daily clinical practice outside tertiary referral centers. CSF levels can best be used in patients under 66 years of age. Given the limited use of this tool in settings outside research facilities, we recommend that the usefulness of CSF biomarkers is studied in a multicenter study. When in the future CSF levels can be reliably measured in plasma, this may become even more relevant. PMID: 32224618 [PubMed - as supplied by publisher]
Source: Dementia and Geriatric Cognitive Disorders - Category: Psychiatry Tags: Dement Geriatr Cogn Disord Source Type: research
Publication date: Available online 2 April 2020Source: Social Science &MedicineAuthor(s): Sae Hwang Han, J. Scott Roberts, Jan E. Mutchler, Jeffrey A. Burr
Source: Social Science and Medicine - Category: Psychiatry & Psychology Source Type: research
Authors: Khosravi S, Harner ME Abstract Mitochondria perform a plethora of functions in various cells of different tissues. Their architecture differs remarkably, for instance in neurons versus steroidogenic cells. Furthermore, aberrant mitochondrial architecture results in mitochondrial dysfunction. This indicates strongly that mitochondrial architecture and function are intimately linked. Therefore, a deep knowledge about the determinants of mitochondrial architecture and their function on a molecular level is of utmost importance. In the past decades, various proteins and protein complexes essential for formatio...
Source: Biological Chemistry - Category: Chemistry Tags: Biol Chem Source Type: research
In conclusion, intravenous neuronal mitochondria-targeted dual-modified novel biomimetic nanosystems are a promising therapeutic candidate for ROS-induced mitochondrial dysfunction in AD. PMID: 32228100 [PubMed - in process]
Source: Drug Delivery - Category: Drugs & Pharmacology Tags: Drug Deliv Source Type: research
No abstract available
Source: Neurology Today - Category: Neurology Tags: In the Pipeline Source Type: research
In conclusion, the different severities of glaucoma do not alter the incidence of subsequent dementia.
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
The objective of the present study is to investigate the most recent neuroimaging procedures in the domain of prediction of transition from MCI to AD dementia for clinical applications and to systematically discuss the machine learning techniques used for the prediction of MCI conversion.MethodsElectronic databases including PubMed, SCOPUS, and Web of Science will be searched from January 1, 2017, to the date of search commencement to provide a rapid review of the most recent studies that have investigated the prediction of conversion from MCI to Alzheimer ’s using neuroimaging modalities in randomized trial or obser...
Source: Systematic Reviews - Category: International Medicine & Public Health Source Type: research
Chem. Commun., 2020, Accepted Manuscript DOI: 10.1039/C9CC09758A, Feature ArticleMadhuparna Roy, Ishita Pal, Arnab K Nath, Somdatta Ghosh Dey The amyloid cascade theory attributes the neurodegeneration observed in Alzheimer ’s disease (AD) to the deposition of amyloid β (Aβ) peptide into plaques and fibrils in the AD brain. The metal... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Chem. Commun. latest articles - Category: Chemistry Authors: Source Type: research
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