5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.

CONCLUSIONS: These data provide a novel non-epigenetic mechanism of action for 5-Aza and its combinatorial activity with venetoclax through the ISR-mediated induction of PMAIP1. PMID: 32054729 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research