5-Azacitidine Induces NOXA to Prime AML Cells for Venetoclax-mediated Apoptosis.
CONCLUSIONS: These data provide a novel non-epigenetic mechanism of action for 5-Aza and its combinatorial activity with venetoclax through the ISR-mediated induction of PMAIP1.
PMID: 32054729 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Jin S, Cojocari D, Purkal JJ, Popovic R, Talaty NN, Xiao Y, Solomon LR, Boghaert ER, Leverson JD, Phillips DC Tags: Clin Cancer Res Source Type: research
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