Safety of MenACWY-CRM vaccine exposure during pregnancy.

This study provides safety information about inadvertent MenACWY-CRM vaccination during pregnancy. METHODS: The evaluated population consisted of pregnant female members of Kaiser Permanente Southern California who inadvertently received MenACWY-CRM at 11-21 years of age during 09/30/2011-06/30/2013 within 28 days prior to conception or during pregnancy. Chart abstraction was conducted to identify pregnancy and birth outcomes, including spontaneous and induced abortions, preterm births, low weight births, and major congenital malformations (MCMs). RESULTS: There were 92 women who received MenACWY-CRM during the pregnancy exposure period, mainly during the first trimester (76.1%). Hispanics represented the largest race/ethnicity category (68.5%). Among the known pregnancy outcomes (n = 66; excluding induced abortions and unknown pregnancy outcomes), the prevalence of spontaneous abortions was 18.2% (n = 12). Among live born infants (n = 55; from 54 pregnancies), 14.5% (n = 8) were born preterm (
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research

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Publication date: Available online 27 March 2020Source: Veterinary MicrobiologyAuthor(s): Adthakorn Madapong, Kepalee Saeng-chuto, Puwich Chaikhumwang, Angkana Tantituvanont, Kriangsak Saardrak, Rafael Pedrazuela Sanz, Joel Miranda Alvarez, Dachrit Nilubol
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Leading scientist Adam Finn warns of stumbles along the way to Covid-19 immunisationThe chances of an individual Covid-19 vaccine project producing a successful outcome are low, one of Britain ’s leading immunisation experts has warned. “Science does not have a track record where most of our vaccine projects work,” Professor Adam Finn, of Bristol University said last week. “We have a track record where most of them don’t work.”Finn ’s warning came as doctors and epidemiologists stressed how difficult it would be to contain the disease until people can be immunised against it.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Vaccines and immunisation Coronavirus outbreak Infectious diseases Medical research Microbiology UK news Science World news Health Society University of Bristol Source Type: news
Ian Lipkin joins Vincent to talk about his experience as a COVID-19 patient, and issues surrounding the disease and SARS-CoV-2 including limiting transmission, antivirals, vaccines, and much more. Hosts: Vincent Racaniello Guest: W. Ian Lipkin Subscribe (free): iTunes, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode Center for Infection and Immunity Control the Contagion videos Timestamps by Jolene. Thanks! Intro music is by Ronald Jenkees. Send your virology questions and comments to twiv@microbe.tv
Source: This Week in Virology - MP3 Edition - Category: Virology Authors: Source Type: podcasts
Our country is facing a national health crisis on a scale that has never been seen before in our lifetimes. The COVID-19 pandemic is unchartered territory —a new strain of an old virus that has so far claimed more than 1,000 lives. Right now, we are all nervous for what’s still to come—not just for ourselves, […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions COVID-19 coronavirus Infectious Disease Source Type: blogs
RARITAN, NJ, March 28, 2020 – The Janssen Pharmaceutical Companies of Johnson &Johnson today announced the VOYAGER PAD study met its primary efficacy and principal safety endpoints, demonstrating the XARELTO® (rivaroxaban) vascular dose (2.5 mg twice daily) plus aspirin (100 mg once daily) was superior to aspirin alone in reducing the risk of major adverse limb and cardiovascular (CV) events by 15 percent in patients with symptomatic peripheral artery disease (PAD) after lower-extremity revascularization, with similar rates of TIMI[1] major bleeding. VOYAGER PAD is the only study to show a significant benefit...
Source: Johnson and Johnson - Category: Pharmaceuticals Tags: Innovation Source Type: news
‚ÄčI have been seeing a lot of second disease and fifth disease—it's that time of year. School is back in session, and winter is just around the corner.The rash-numbering system for these diseases is now a historical footnote, but fifth disease is still commonly used by physicians to refer to erythema infectiosum, a parvovirus. I suspect that this system was created as a memory device for similar names and the obscure Latin terms used for these diseases. Erythema infectiosum is also easy to confuse with the many other erythema rashes such as erythema migrans, erythema marginatum, erythema toxicum, and erythema multif...
Source: M2E Too! Mellick's Multimedia EduBlog - Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Conclusions Listeriosis in pregnancy can result in severe adverse maternal, fetal, and neonatal outcomes including miscarriage, preterm labor, fetal death, and neonatal meningitis and sepsis. Early treatment has been shown to improve fetal and neonatal outcomes; therefore, prevention with education and early diagnosis prompting treatment will improve overall outcomes. Relevance The incidence of listeriosis is expected to rise in the coming years due to changes in the US population, with increasing numbers of older Americans and Hispanic individuals, both of whom are at higher risk. Pregnant women contract listeriosis ...
Source: Obstetrical and Gynecological Survey - Category: OBGYN Tags: CME ARTICLES Source Type: research
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog aka Tropical Travel Trouble 007 When you think tropical medicine, malaria has to be near the top. It can be fairly complex and fortunately treatment has become a lot simpler. This post is designed to walk you through the basic principals with links to more in depth teaching if your niche is travel medicine, laboratory diagnostics or management of severe or cerebral malaria. If you stubbled on this post while drinking a cup of tea or sitting on the throne and want a fe...
Source: Life in the Fast Lane - Category: Emergency Medicine Authors: Tags: Clinical Cases Tropical Medicine malaria Plasmodium plasmodium falciparum plasmodium knowles plasmodium malariae plasmodium ovale plasmodium vivax Source Type: blogs
Sign-up here for a set of week-by-week newsletters so you can follow your baby’s development from now until the beautiful moment of birth. Get Dr. Greene's Pregnancy Newsletter Sign up for Dr. Greene's FREE week-by-week newsletter, timed to your pregnancy to keep you up to date on every stage of your baby's development. Success! Now check your email to confirm your subscription. There was an error submitting your subscription. Please try again. First Name Your baby's due date? ...
Source: Conversations with Dr Greene - Category: Child Development Authors: Tags: Uncategorized Source Type: blogs
Listeria monocytogenes is a Gram-positive intracellular pathogen that causes spontaneous abortion in pregnant women, as well as septicemia, meningitis, and gastroenteritis, primarily in immunocompromised individuals. Although L. monocytogenes can usually be effectively treated with antibiotics, there is still around a 25% mortality rate with individuals who develop clinical listeriosis. Neutrophils are innate immune cells required for the clearance of pathogenic organisms, including L. monocytogenes. The diverse roles of neutrophils during both infectious and noninfectious inflammation have recently gained much attention. ...
Source: Infection and Immunity - Category: Infectious Diseases Authors: Tags: Host Response and Inflammation Source Type: research
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