Cytogenetic testing of pregnancy loss tissue, a meta-analysis

Publication date: Available online 15 February 2020Source: Reproductive BioMedicine OnlineAuthor(s): M.A.J. Smits, M. van Maarle, G. Hamer, S. Mastenbroek, M. Goddijn, M. van WelyAbstractMany clinics offer routine genetic testing of pregnancy loss tissue. The present review presents a comprehensive literature search and meta-analysis on chromosomal abnormality rates of pregnancy loss tissue from women with a single or recurrent pregnancy loss. We included 55 studies, published since 2000, which we analyzed on the prevalence of test failure rates, abnormality detection rates and percentages of trisomy, monosomy X, structural abnormalities and other clinically (ir)relevant abnormalities detected by conventional karyotyping, array-CGH, SNP array, FISH and MLPA. The detected prevalence of chromosomal abnormalities was 48% (95% CI: 39-57) using aCGH, 38% (95% CI: 28-49) with FISH, 25% (95% CI: 12-42) using MLPA, 60% (95% CI: 58-63) using SNP array and 47% (95% CI: 43-51) with conventional karyotyping. The percentage of detected abnormalities did not differ between women that suffered from a sporadic (46% (95% CI: 39-53)) and recurrent (46% (95% CI: 39-52)) pregnancy loss. In view of the high prevalence of chromosomal abnormalities in pregnancy loss tissue, and the low chance of recurrence of the same chromosomal aberration, we conclude that detection of specific chromosomal abnormalities in pregnancy loss tissue has no clinical benefit. Therefore, routine testing of pregnancy loss...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research

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Source: The International Journal of Cardiovascular Imaging - Category: Radiology Source Type: research
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized COVID-19 UnitedWeRise20Disaster Source Type: news
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Source: Texto e Contexto - Enfermagem - Category: International Medicine & Public Health Source Type: research
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Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Featured Global Headlines Health Human Rights TerraViva United Nations OPINION/NGO Source Type: news
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Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Condition:   Pregnancy Related Intervention:   Dietary Supplement: Methionine Intake Sponsor:   University of British Columbia Not yet recruiting
Source: - Category: Research Source Type: clinical trials
Condition:   Ectopic Pregnancy; Assisted Reproductive Technology Intervention:   Procedure: I and II level ART procedure Sponsor:   Istituto Clinico Humanitas Completed
Source: - Category: Research Source Type: clinical trials
Condition:   Pregnancy Related Intervention:   Dietary Supplement: Methionine Intake Sponsor:   University of British Columbia Not yet recruiting
Source: - Category: Research Source Type: clinical trials
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