Expression of NFIA and NFIB within the murine spinal cord

Publication date: Available online 15 February 2020Source: Gene Expression PatternsAuthor(s): Elise Matuzelski, Tracey J. Harvey, Danyon Harkins, Thuan Nguyen, Marc J. Ruitenberg, Michael PiperAbstractThe Nuclear factor I proteins comprise a family of transcription factors that are expressed in many developing and mature cell populations, including within the central nervous system. Within the embryonic mouse spinal cord, NFIA and NFIB are expressed by neural progenitor cells lining the central canal, where they act to promote astrocytic and oligodendrocytic lineage specification. Cells lining the mature spinal cord central canal retain characteristics of neural progenitor cells, but the expression of NFIA and NFIB within the mature spinal cord at a cell-type-specific level remains undefined. Here, we investigated where these two transcription factors are expressed within the adult mouse spinal cord. We reveal that both factors are expressed in similar cohorts of mature cells, including ependymal cells, interneurons and motor neurons. We also show robust and widespread expression of NFIA and NFIB within nestin-expressing cells following injury to the spinal cord. Collectively, these data provide a basis to further define what functional role(s) NFIA and NFIB play within the adult spinal cord.
Source: Gene Expression Patterns - Category: Genetics & Stem Cells Source Type: research

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Condition:   Spinal Cord Contusion Intervention:   Biological: Human Allogeneic Umbilical Cord Blood Mononuclear Cells (hUCBMCs) systemic (i.v.) infusions Sponsors:   Sklifosovsky Institute of Emergency Care;   National Medical Research Center for Cardiology, Ministry of Health of Russian Federation Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusion: I/R injury of the spinal cord can be successfully demonstrated by aortic clamping in this surgical model. Betanin/Copper sulphate has ameliorative effects against operative I/R injury. Low toxicity of those agents makes them ideal targets for clinical research for this purpose. PMID: 32223592 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Conclusion: Current surgical treatment of post-traumatic syringomyelia involves restoration of normal CSF flow dynamics; further prospective work is needed to correlate the clinical state, radiographic measures, and efficacy of surgical intervention. PMID: 32223591 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Authors: Pastuszka A, Bohosiewicz J, Olejek A, Zamłyński J, Horzelska E, Koszutski T Abstract Objective: Chemical and mechanical injury in myelomeningocele (MMC) during the fetal life results in functional disorders of multiple organs. Prenatal MMC repair reduces sequelae of spinal cord injury.Design: Histopathological evaluation of dura mater and skin specimens to assess the severity of inflammatory changes.Setting: Histopathological laboratory and operated patients.Participants: 45 cases (Group I)-intrauterine surgery due to MMC and 42 cases (Group II)-postnatal surgery.Outcome measures: Specimens of the skin a...
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
Immunization with neural derived peptides (INDP), as well as scar removal (SR) and the use of matrices with bone marrow-mesenchymal stem cells (MSCs), have been studied separately and proven to induce a functional and morphological improvement after spinal cord injury (SCI). Herein, we evaluated the therapeutic effects of INDP combined with SR and a fibrin glue matrix (FGM) with MSCs (FGM-MSCs), on motor recovery, axonal regeneration-associated molecules and cytokine expression, axonal regeneration (catecholaminergic and serotonergic fibers), and the induction of neurogenesis after a chronic SCI. For this purpose, female a...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Publication date: Available online 31 March 2020Source: Neuroscience LettersAuthor(s): Zhongjie Zhou, Bowen Hu, Qiunan Lyu, Tianhang Xie, Juehan Wang, Qianyun Cai
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
Journal of Neurotrauma, Ahead of Print.
Source: Journal of Neurotrauma - Category: Neurology Authors: Source Type: research
Journal of Neurotrauma, Ahead of Print.
Source: Journal of Neurotrauma - Category: Neurology Authors: Source Type: research
Journal of Neurotrauma, Ahead of Print.
Source: Journal of Neurotrauma - Category: Neurology Authors: Source Type: research
AbstractDespite the prominence of sexual health concerns in the spinal cord injury (SCI) population, education regarding sexual functioning and related matters is not well integrated into rehabilitation processes or ongoing care in SCI. Conceptual sexual health care frameworks encompass a range of biopsychosocial factors and recommend utilizing an interdisciplinary approach to meet the diverse needs of individuals with disabilities. Yet, it is rare to have a truly integrated treatment team dedicated to sexual health and functioning in SCI rehabilitative settings. The program described in this article attempts to align itse...
Source: Sexuality and Disability - Category: Disability Source Type: research
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