Cholera: what every doctor should know

In 1817 there was a major outbreak of cholera in India that spread to Asia and Europe. The disease reached England in 1831, and war in America and Europe helped its spread. Here the author describes the bacteriology, pathogenesis, diagnosis, treatment and prevention of this notifiable disease.
Source: Trends in Urology and Men's Health - Category: Urology & Nephrology Authors: Tags: Infections Source Type: research

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Abstract On October 6, 2017, the Zambia Ministry of Health declared a cholera outbreak in Lusaka. By December, 1,462 cases and 38 deaths had occurred (case fatality rate, 2.6%). We conducted a case-control study to identify risk factors and inform interventions. A case was any person with acute watery diarrhea (≥ 3 loose stools in 24 hours) admitted to a cholera treatment center in Lusaka from December 16 to 21, 2017. Controls were neighbors without diarrhea during the same time period. Up to two controls were matched to each case by age-group (1-4, 5-17, and ≥ 18 years) and neighborhood. Surveyors interview...
Source: The American Journal of Tropical Medicine and Hygiene - Category: Tropical Medicine Authors: Tags: Am J Trop Med Hyg Source Type: research
We present an integrated approach in the form of a disease management model for analyzing spatio-temporal dynamics of disease in connection with other determinants. Our approach aligns spatio-temporal profiles of disease with other driving factors in public health context to identify hotspots and patterns of disease and features of interest in the identified locations. We evaluate our model against cholera disease outbreaks from 2015–2019 in Punjab province of Pakistan. The experimental results showed that the presented model effectively address the complex dynamics of disease incidences in the presence of other ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
Conclusion: The current study identified phage type 27 as the most dominant type and serotype Ogawa was found continuous in circulation throughout the year which has caused recent cholera outbreaks in India during the past years. Phage sensitivity data propose an alternative cost-effective approach to prevent cholera outbreak by therapeutic uses of typing phages irrespective of origin or clonality of the strains.
Source: Journal of Global Infectious Diseases - Category: Infectious Diseases Authors: Source Type: research
Many of the people I support in Kinshasa have no money, no soap, no water – and when they are struggling to breathe, no ventilatorsCoronavirus – latest updatesSee all our coronavirus coverageWe ’re used to emergencies and people dying in the Democratic Republic of the Congo, whether it’s a result of the long-runningconflict or Ebola, cholera and malaria. But coronavirus has knocked us for six, because it has affected people we are very close to.I ’ve been working in development for decades, but I have to admit I have shed tears these past few weeks.Continue reading...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Global development Democratic Republic of the Congo Coronavirus outbreak Infectious diseases Science World news Africa Source Type: news
Silicon Valley start-up Zenysis drafted in to help authorities tackle disease
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news
Here’s betting you wouldn’t want anyone blowing smallpox scabs up your nose. But you might feel differently if you lived in 15th century China. Long ago, the Chinese recognized that people who had contracted smallpox once were immune to reinfection. They came up with the idea of preserving scabs from individuals who had suffered mild cases, drying them out, crushing them to a powder and blowing them up the nostril. For boys it was the right nostril, for girls it was the left because, well, 15th century. That is how the story of vaccines usually begins, though that version is decidedly incomplete. For one thing,...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized COVID-19 Explainer health Source Type: news
Franciscka Lucien is Executive Director of the Institute for Justice &Democracy in Haiti. Joel Curtain is the Director of Advocacy at Partners in Health.By Franciscka Lucien and Joel CurtainPORT-AU-PRINCE, Haiti and BOSTON, May 7 2020 (IPS) The World Bank and the International Monetary Fund (IMF) have a historic opportunity to help stabilize a world reeling from COVID-19. Doing so will require the institutions to change course and aggressively support poor countries’ ability to invest broadly in the government services their populations need. The pandemic is exposing the consequences of four decades of reduced p...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Economy & Trade Education Financial Crisis Global Headlines Health Humanitarian Emergencies Labour Latin America & the Caribbean TerraViva United Nations Source Type: news
A young boy in Pakistan receives an oral polio vaccine (OPV). Credit: Ashfaq Yusufzai/IPSBy Laura MackenzieMay 6 2020 (IPS) Interruptions to vaccination programmes caused by the COVID-19 pandemic could result in new waves of measles or polio outbreaks, health experts warn. A growing number of one-off immunisation campaigns and national routine vaccine introductions are being delayed amid social distancing and other measures to curb the spread of SARS-CoV-2, leaving millions unprotected. With both preventive campaigns and routine immunisations impacted, “we’ll have an increasing number of children who will becom...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health TerraViva United Nations Source Type: news
In this report, we produced CT in El Tor biotype strains using simple media and single-phase culture conditions. A single point mutation in ToxT, a transcriptional activator of toxin co-regulated pilus (TCP) and CT, enabled the El Tor biotype strains to produce CT in similar quantities as classical biotype strains in single-phase laboratory culture conditions. CT production capacity varied between El Tor biotype strains. Wave 2 and 3 atypical El Tor strains tended to produce more CT than prototype Wave 1 strains. Wave 2 and 3 strains lack neutral fermentation; however, the capacity for neutral fermentation was not associat...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
PMID: 32352952 [PubMed]
Source: MMWR Morb Mortal Wkl... - Category: Epidemiology Authors: Tags: MMWR Morb Mortal Wkly Rep Source Type: research
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