Cardiovascular Disease Guideline Adherence: An RCT Using Practice Facilitation
The objective of the study is to determine whether practice facilitation is effective in increasing the proportion of patients meeting the Million Hearts ABCS outcomes: (A) aspirin when indicated, (B) blood pressure control, (C) cholesterol management, and (S) smoking screening and cessation intervention.DesignThe study used a stepped-wedge cluster RCT design with 4 intervention waves. Data were extracted for 13 quarters between January 1, 2015 and March 31, 2018, which encompassed the control, intervention, and follow-up periods for all waves, and analyzed in 2019.Setting/participantsA total of 257 small independent primary care practices in New York City were randomized into 1 of 4 waves.InterventionThe intervention consisted of practice facilitators conducting at least 13 practice visits over 1 year, focused on capacity building and implementing system and workflow changes to meet cardiovascular disease care guidelines.Main outcome measuresThe main outcomes were the Million Hearts’ ABCS measures. Two additional measures were created: (1) proportion of tobacco users who received a cessation intervention (smokers counseled) and (2) a composite measure that assessed the proportion of patients meeting treatment targets for A, B, and C (ABC composite).ResultsThe S measure improved when comparing follow-up with the control period (incidence rate ratio=1.152, 95% CI=1.072, 1.238, p
Publication date: Available online 1 April 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Florina Zakany, Tamas Kovacs, Gyorgy Panyi, Zoltan Varga
Research by Peter Tontonoz could open the door to new therapies for people with high cholesterol and other lipid disorders. (read more)
Atkins, Paleo or Zone – whichever diet you follow, you’ll probably only lose a bit of weight, and improvements to your cholesterol may disappear within a year
Org. Biomol. Chem., 2020, Advance Article DOI: 10.1039/D0OB00437E, PaperMaina Takahashi, Junya Shirasaki, Naoko Komura, Katsuaki Sasaki, Hide-Nori Tanaka, Akihiro Imamura, Hideharu Ishida, Shinya Hanashima, Michio Murata, Hiromune Ando GM3 gangliosides have been synthesizedvia late-stage α-sialylation using a macro-bicyclic sialyl donor.19F solid-state NMR analysis of the C5-NHTFAc GM3 analog on a model membrane revealed the influence of cholesterol on glycan dynamics. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
CONCLUSION: TT extract and its saponin fraction exerted anti-inflammatory effects on HUVEC and HBMEC lines and reduced the expression of ICAM-1, VCAM-1, and E-selectin. However, the anti-inflammatory effect of aqueous extract was greater than that of saponin fraction. Therefore, TT could be considered as a potential candidate for the treatment or prevention of atherosclerosis. PMID: 32224542 [PubMed - in process]
Purpose of review The goal of this review is to present recent models of the filtration barrier that may suggest mechanism-based treatments for proteinuric renal disease. The vast majority of renal failure occurs in diseases of glomerular proteinuria. The physiology of the filtration barrier remains incompletely understood, preventing invention of mechanism-based therapies. Research is currently dominated by molecular biology approaches to the kidney instead of engineering-based filtration and transport models. Recent findings Reexamination of two older paradigms (basement membrane and slit diaphragm) and critical ana...
People who initiate statins or antihypertensive medicines are more likely to become obese or physically inactive compared with people who do not, a study published in the Journal of the American Heart Association suggests.
Contributors : Masashi Muramatsu ; Suguru Nakagawa ; Tsuyoshi Osawa ; Takashi MinamiSeries Type : Expression profiling by arrayOrganism : Mus musculusTo elucidate the molecular mechanisms behind corneal angiogenesis in Dscr-1-/- mice, we performed microarray analysis using intact corneas from B6, Dscr-1-/- mice, ApoE-/- mice, Dscr-1-/- and ApoE-/- double null mutant mice and sutured corneas from B6, Dscr-1-/- and Dscr-1 Tg mouse.
(Science China Press) Eggs are nutrient-dense while also loaded with abundant cholesterol, thus making the public hesitant about consumption. Based on the China-PAR project, Xia and her colleagues observed U-shaped associations of egg consumption with incident cardiovascular disease (CVD) and total death among 102136 adults. They highlighted that moderate egg consumption of 3-6/week was beneficial and worth of recommendation for CVD prevention.