Assessment of efficacy of oseltamivir-azithromycin combination therapy in prevention of influenza-a (H1N1) infection complications and rapidity of symptom relief.

This study aimed to assess the efficacy of Oseltamivir-Azithromycin combination therapy for prevention of Influenza-A(H1)pdm09 infection associated complications and early relief of influenza symptoms.Methods: In a retrospective observational cohort study, Influenza-A(H1)pdm09 infection hospitalized patients were identified and divided into two groups based on the initial therapy. Group-AV patients were initiated on Oseltamivir without any antibiotic in treatment regimen while Group-AV+AZ patients were initiated on Oseltamivir and Azithromycin combination therapy for at least 3-5 days. Patients were evaluated for different clinical outcomes.Results: A total of 227 and 102 patients were identified for Group-AV and Group-AV+AZ respectively. The identified patients of both groups were mostly unvaccinated. Multivariate regression analysis showed that incidences of secondary bacterial infections were significantly less frequent (23.4% vs 10.4%; P-value=0.019) in Group-AV+AZ patients. Group-AV+AZ patients were associated with shorter length of hospitalization (6.58 vs 5.09 days; P-value=
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research

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harine E. Magor RIG-I plays an essential role in the duck innate immune response to influenza infection. RIG-I engages the critical adaptor protein mitochondrial antiviral signaling (MAVS) to activate the downstream signaling pathway. The influenza A virus non-structural protein PB1-F2 interacts with MAVS in human cells to inhibit interferon production. As duck and human MAVS share only 28% amino acid similarity, it is not known whether the influenza virus can similarly inhibit MAVS signaling in avian cells. Using confocal microscopy we show that MAVS and the constitutively active N-terminal end of duck RIG-I (2CARD) c...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
AbstractRecently, the novel coronavirus disease 2019 (COVID-19) started spreading in Japan. Therefore, the number of patients with severe COVID-19 requiring extracorporeal membranous oxygenation (ECMO) is expected to increase. A working group has been formed to provide telephone consultation services for cases with severe respiratory failure caused by COVID-19 in Japan. During the first 13  days of the service, there were 12 consultations. For each consultation, we advised the patient on the initiation of ECMO and arranged transportation for patients with ECMO. Based on experience from the H1N1 influenza pandemic, t...
Source: Journal of Intensive Care - Category: Intensive Care Source Type: research
After World War I, something much more deadly arrived on America's shores: the H1N1 influenza virus, known as the Spanish flu.
Source: Health News: - Category: Consumer Health News Source Type: news
Abstract BACKGROUND: Hospital-acquired viral respiratory tract infections (VRTIs) cause significant morbidity and mortality in neonatal patients. This includes escalation of respiratory support, increased length of hospital stay, and need for home oxygen, as well as higher healthcare costs. To date, no studies have compared population rates of VRTIs across age groups. AIM: Quantify the rates of hospital-acquired VRTIs in our neonatal population compared with other inpatient age groups in Nottinghamshire, UK. METHODS: We compared all hospital inpatient PCR-positive viral respiratory samples between 2007 a...
Source: Neonatology - Category: Perinatology & Neonatology Authors: Tags: Neonatology Source Type: research
In this study, a meaningful 3D quantitative structure-activity relationship model (comparative molecular field analysis R2 = 0.997, q2 = 0.527, s = 0.064, F = 282.663) was built to understand the chemical-biological interactions between their activities and neuraminidase. Molecular docking was used to predict binding models between curcumin derivatives and neuraminidase. Real-time polymerase chain reactions showed that the five active curcumin derivatives might have direct effects on viral particle infectivity in H1N1-infected lung epithelial (MDCK) cells. Neuraminida...
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research
This article is republished from The Conversation under a Creative Commons license. Read the original article. The post Coronavirus: Country Comparisons are Pointless Unless We Account for These Biases in Testing appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Global Headlines Health TerraViva United Nations Coronavirus Source Type: news
Authors: Flahault A, Zylberman P Abstract Influenza epidemics occur regularly and prediction of their conversion to pandemics and their impact is difficult. Coordination of efforts on a global scale to control or reduce the impact is fraught with potential for under and overreaction. In light of the 1956 pandemic and more recently the SARS and H1N1 pandemics, the public health community took steps toward strengthening global surveillance and a coordinated response in keeping with the continuing memory of the tragedy seen in 1918. The scientific, professional, and technical resources of the 21st century are now adva...
Source: Public Health Reviews - Category: International Medicine & Public Health Tags: Public Health Rev Source Type: research
Throughout history, infectious diseases represent a major global threat to human life and health, knowing neither geographic nor political borders. In 1918 the “Spanish flu” pandemic, caused by the H1N1 influenza A virus, led to catastrophic consequences with a global mortality toll of more than 50 million people (greater than the two world wars). The impact of this influenza virus was not confined to a single period; to date, three subsequent outbreak s (1957, 1968, and 2009, the last called “Swine flu”) resulted from descendants of the initial virus, which acquired one or more genes through reassortment [1].
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
Purpose of review Mass gathering events bring people from across all continents increasing the risk of spread of aerosol transmissible respiratory tract infections. Respiratory tract infections for instance in pilgrims attending the world's largest recurring annual pilgrimage, the Hajj are common. We review recent literature on viral and bacterial infectious diseases with special focus on the Hajj. Recent findings The prevalence of bacterial and viral infections continue to increase, because of the acquisition of rhinovirus, coronaviruses (229E, HKU1, OC43), influenza A H1N1, Streptococcus pneumoniae, Haemophilus infl...
Source: Current Opinion in Pulmonary Medicine - Category: Respiratory Medicine Tags: INFECTIOUS DISEASES: Edited by Michael S. Niederman and Alimuddin Zumla Source Type: research
Conclusions […..............We demonstrate the anti-IAV activity of WEPO [Portulaca] and strongly recommend the use of WEPO, as an herbal regimen, to prevent and treat H1N1 infection at an early stage]   Advice to my patients:   If you wish you can use portulaca [as mother tincture in wintertime as it grows only as avegetable during the summer months]   Take 30-40 drops if you have/ had a flu, on top of everything else you are doing. [children: 1 year 1/4 dose,3 years 1/3 dose.7 years 1/2 dose,13 years 3/4 dose, between these ages interpolate, anyhow Portulaca is not toxic] Don't take in pregnancy wit...
Source: Headlines - Category: Radiology Source Type: news
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