Association of aspirin resistance with 4 ‐hydroxynonenal and its impact on recurrent cerebral infarction in patients with acute cerebral infarction

ACI patients with AR have a higher plasma 4 ‐HNE level, suggesting that 4‐HNE may be a factor contributing to aspirin resistance. And AR has a higher CI recurrence rate compared with the patients without AR. AbstractObjectivesTo investigate the association of aspirin resistance (AR) with the plasma 4 ‐hydroxynonenal (4‐HNE) level and its impact on recurrent cerebral infarction (CI) in patients with acute cerebral infarction (ACI) who were receiving aspirin therapy.MethodsOne hundred and fifty ‐four ACI patients who previously received aspirin therapy (100 mg/day) were enrolled. Whole urine (for measuring 11dhTXB2 and creatinine) along with blood (for measuring the plasma 4‐HNE level) were collected at least 7 days after the patients received aspirin. A cutoff of 1500 pg/mg of 11dh TXB2/ creatinine was used to determine AR. A follow‐up period to monitor recurrence CI events was 1 year. In addition, blood testing was performed when the patients were first admitted to hospital.ResultsForty ‐six of the 154 enrolled patients (29.9%) were found to be AR. No statistical difference in age, sex, hypertension, diabetes mellitus, coronary disease, smoking status, NIHSS score, TOAST classification, platelet count, thrombocytocrit, LDL‐C, HDL‐C, TG, and TC was found between the AR and asp irin‐sensitive (AS) patients, but the plasma 4‐HNE level was found to be higher in the AR patients than AS patients (p 
Source: Brain and Behavior - Category: Neurology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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Source: American Journal of Hypertension - Category: Cardiology Authors: Tags: Am J Hypertens Source Type: research
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Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
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Source: Arquivos Brasileiros de Cardiologia - Category: Cardiology Source Type: research
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Source: Current Hypertension Reports - Category: Primary Care Source Type: research
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Source: Johnson and Johnson - Category: Pharmaceuticals Source Type: news
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Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
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