Antibacterial activity profile of miramistin in in vitro and in vivo models

ConclusionsThe results of this work provide systematic data on antibacterial efficacy of miramistin. They also underscore the need in relevant in vivo models for evaluation of antiseptics' efficacy. While the existing in vitro methods can be successfully applied at the discovery stages, it is necessary to use more realistic in vivo models at more advanced development stages. The observed selectivity reversal effect should be taken into account when carrying out the antiseptics’ efficacy testing and surface disinfection procedures.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research