Removal of sinks and bathing changes to control multidrug-resistant Gram-negative bacteria in a neonatal intensive care unit: a retrospective investigation

Publication date: Available online 23 January 2020Source: Journal of Hospital InfectionAuthor(s): M. Tracy, L. Ryan, H. Samarasekara, M. Leroi, A. Polkinghorne, J. Branley
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research

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Authors: Ali S, Khan MT, Khan AS, Mohammad N, Khan MM, Ahmad S, Noor S, Jabbar A, Daire C, Hassan F Abstract Anti-tuberculosis therapy involves the combination of drugs to hamper the growth of Mycobacterium tuberculosis (MTB). The emergence of multidrug-resistant tuberculosis (MDR-TB) is a global concern. Pakistan has been ranked 5th position in terms of a high burden of MDR-TB in the world. The aim of the current study was to investigate the prevalence of drug resistance in MTB in Khyber Pakhtunkhwa. Random samples were collected from 25 districts using the simple random sampling formula. All samples were processe...
Source: Polish Journal of Microbiology - Category: Microbiology Tags: Pol J Microbiol Source Type: research
Shenmai injection suppresses multidrug resistance in MCF-7/ADR cells through the MAPK/NF-κB signalling pathway. Pharm Biol. 2020 Dec;58(1):276-285 Authors: Yang L, Zhang C, Chen J, Zhang S, Pan G, Xin Y, Lin L, You Z Abstract Context: Shenmai Injection (SMI) is usually used to treat atherosclerotic coronary heart disease and viral myocarditis in China. However, the effect of SMI on multidrug resistance has not been reported.Objective: To investigate the reversal effect of SMI in adriamycin (ADR) resistant breast cancer cell line (MCF-7/ADR) and explore the related molecular mechanisms.Materials a...
Source: Pharmaceutical Biology - Category: Drugs & Pharmacology Tags: Pharm Biol Source Type: research
This study represents the first characterization of a mobilizable antibiotic resistance island in a species of Rheinheimera and provides evidence that Rheinheimera spp. could be important reservoirs and vehicles for ARGs in the Yellow Sea area.
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Abstract To ameliorate multidrug resistance (MDR) observed in leukemia cells, nanomicelles modified by transferrin (Tf-M-DOX/PSO), coencapsulating doxorubicin (DOX) and psoralen (PSO), were designed, synthesized and tested in K562 and doxorubicin-resistant K562 (K562/DOX) cells. In vitro drug release kinetics for constructed nanomicelles were measured using high-performance liquid chromatography. Characterization of the produced nanomicelles was completed using transmission electron microscopy and dynamic light scattering. Uptake of the nanomicelles in K562 cells was investigated using both confocal microscopy and...
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
The Korea Centers for Disease Control&Prevention has implemented a review process for the approval of new drugs used to treat patients with multidrug-resistant tuberculosis (MDR-TB) since September 2016. Therefore, this study aimed to evaluate the efficacy and safety of these new drugs bedaquiline (Bdq) and delamanid (Dlm).
Source: Respiratory Medicine - Category: Respiratory Medicine Authors: Source Type: research
nni Colotti The development of drug resistance is one of the main causes of failure in anti-cancer treatments. Tumor cells adopt many strategies to counteract the action of chemotherapeutic agents, e.g., enhanced DNA damage repair, inactivation of apoptotic pathways, alteration of drug targets, drug inactivation, and overexpression of ABC (Adenosine triphosphate-binding cassette, or ATP-binding cassette) transporters. These are broad substrate-specificity ATP-dependent efflux pumps able to export toxins or drugs out of cells; for instance, ABCB1 (MDR1, or P-glycoprotein 1), overexpressed in most cancer cells, confers t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
Publication date: 1 August 2020Source: Chemical Engineering Journal, Volume 393Author(s): He Wang, Baohua Zhao, Wenjing Dong, Yuan Zhong, Xiaorong Zhang, Yali Gong, Rixing Zhan, Malcolm Xing, Jianxiang Zhang, Gaoxing Luo, Wei Qian
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Publication date: Available online 3 April 2020Source: Journal of Global Antimicrobial ResistanceAuthor(s): Sana Dhaouadi, Leila Soufi, Amani Hamza, Didier Fedida, Chtioui Zied, Emna Awadhi, Mohamed Mtibaa, Bilel Hassen, Ameur Cherif, Carmen Torres, Mohamed Salah Abbassi, Ramzi Boubaker Landolsi
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Abstract The aim of this study was to determine the spontaneous decolonization period and characteristics in a prospective cohort of newborns colonized by multidrug-resistant organisms, after their discharge from the neonatal intensive care unit. Multidrug resistance is defined as bacterial non-susceptibility to ≥ 1 agent of ≥ 3 antimicrobial categories. In total, 618 newborns were included in the study, of which 173 (28.0%) presented a positive culture for multidrug-resistant microorganisms, and of these, 52 (30.1%) were followed up in this study. The most frequent intrinsic factors were be born by cesarean...
Source: Revista do Instituto de Medicina Tropical de Sao Paulo - Category: Tropical Medicine Authors: Tags: Rev Inst Med Trop Sao Paulo Source Type: research
Authors: Chakrabarti A, Singh S Abstract Introduction: Since the emergence of Candida auris infection in 2009, the disease has been reported from multiple countries within a decade. The infection is classified under urgent threat, as it is multi-drug resistant, causes high mortality, spreads easily in hospital setting and is difficult to identify. Whole-genome sequencing has provided insights into this organisms biology and epidemiology. A comprehensive review of those issues would help the clinicians and scientists facing C. auris infection.Areas covered: We reviewed the epidemiological trends of C. auris infectio...
Source: Expert Review of Anti-Infective Therapy - Category: Infectious Diseases Tags: Expert Rev Anti Infect Ther Source Type: research
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