Identification and Evaluation of Controlled Trials in Pediatric Cardiology: Crowdsourced Scoping Review and Creation of Accessible Searchable Database

Publication date: Available online 15 February 2020Source: Canadian Journal of CardiologyAuthor(s): Jenna Ashkanase, Nassr Nama, Ryan Vimukthie Sandarage, Joshua Penslar, Ronish Gupta, Sophia Ly, Melissa Wan, Phillip Tsang, Alex Nantsios, Erik Jacques, Hsin Yun Yang, Conrad Ian Tsang, Hajra Mazhar, Gang Xu, Maria Rodriguez, Samantha Gerber, Laurie M. Laird, Margaret Sampson, Derek T. Wong, James D. McNallyAbstractCardiac disease in children is associated with significant morbidity and mortality as well as increased health resource utilization. There is a perception that there is a paucity of high-quality studies, particularly randomized controlled trials (RCTs), in the field of pediatric cardiology. We sought to identify, examine, and map the range of RCTs conducted in children with cardiac conditions, including the development of a searchable open-access database. A literature search was conducted encompassing MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from inception to 2018. All English-language RCTs enrolling children (age 0-21 years) with cardiac conditions were included. Data extraction and risk of bias assessments were performed in duplicate via crowdsourcing for each eligible study and entered into an online database. A total of 933 RCTs met eligibility criteria. Median trial recruitment was 49 patients (IQR: 30–86) with 18.9% of studies (N=176) including more than 100 patients. A wide variety of populations and interventions were enc...
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research

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Authors: Mahtta D, Virani SS PMID: 32267794 [PubMed - as supplied by publisher]
Source: Journal of Medical Economics - Category: Health Management Tags: J Med Econ Source Type: research
discussion of the undercount of Covid deaths. And no, death certificates aren't going to let us get a true final tally. They are an excellent example of the reification of data. The cause of death may be given as pneumonia, or even just respiratory arrest, or it may be attributed to some comorbidity and the contribution of the virus to the death may not be noted. Doctors aren't trained to fill these out in any particular way and again, if the person doesn't have laboratory confirmed Covid-19 it will very likely not be on the death certificate even if everybody knows that's almost certainly what it was.Outside of the U.S., ...
Source: Stayin' Alive - Category: American Health Source Type: blogs
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Source: Coronary Artery Disease - Category: Cardiology Tags: Contrast Nephropathy Source Type: research
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Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
(Natural News) Anyone who wants to stay fit and healthy understands the importance of exercising regularly. Being physically active can bring significant improvements to one’s health, including reducing the risk of certain conditions like heart disease and cancer. Thankfully, you don’t need to go to the gym every day to consider yourself “physically active” enough...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
DiscussionWe expect to see a reduced number/duration of RF applications required to achieve effective lesion creation, and consequently a decrease in total procedure/fluoroscopy times. Although a significant improvement in procedural success rates (acute/long term) might not be feasible to demonstrate (given the relatively high success rate of the standard ablation method), the possible decrease in procedure duration and the consequential reduction of radiation exposure has important clinical implications for both operators and patients undergoing the procedure.Trial registrationClinicalTrials,NCT04078685. Retrospectively ...
Source: Trials - Category: Research Source Type: clinical trials
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Source: Dr. Smith's ECG Blog - Category: Cardiology Authors: Source Type: blogs
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Conclusion: Risk factors, aetiology, and precipitating factors of HF in de novo and ADCHF differ. De novo HF also had lower 1-year mortality and 3-month mortality compared to ADCHF. PMID: 32252602 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Research into cancer, heart disease, HIV, MS, Alzheimer ’s, gene therapy, opioid addiction, epilepsy, blindness — all abruptly stopped in mid-March.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
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