Icotinib: efficacy in different solid tumors and gene mutations

This article reviews the efficacy of icotinib in different solid tumors with different epidermal growth factor receptor alterations.
Source: Anti-Cancer Drugs - Category: Cancer & Oncology Tags: Review Articles Source Type: research

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CONCLUSION: RWD is a useful method to audit NTCP models in clinical practice. The NTCP models to predict AET in NSCLC patients showed moderate predictive accuracy. For clinical practice, the V50Gy seems to be most stable for dose de-escalation without compromising safety and efficacy. PMID: 32114266 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
In conclusion, the concept of an epigenetic clock is compelling, but caution should be taken in interpreting associations with age acceleration. Association tests of age acceleration should include age as a covariate. A Discussion of Recent Work on Allotopic Expression of Mitochondrial Genes at the SENS Research Foundation https://www.fightaging.org/archives/2020/02/a-discussion-of-recent-work-on-allotopic-expression-of-mitochondrial-genes-at-the-sens-research-foundation/ A paper published last month outlines recent progress on allotopic expression of mitochondrial genes carried out by the SENS Research ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Chronic inflammation is a risk factor for cancer and cancer mortality. There are numerous reasons as to why this might be the case, some much more proven and settled than others, but the research here is focused on metastasis, the spread of cancerous cells throughout the body. Since cancer mortality is largely determined by whether or not a tumor progresses to the point of metastasis, we should not be surprised that researchers can identify mechanisms linking inflammation with metastasis. Dysregulated inflammation is recognized as one of the hallmarks of cancer and is involved in tumor initiation, progression, an...
Source: Fight Aging! - Category: Research Authors: Tags: Daily News Source Type: blogs
ConclusionSABR of 60 Gy in eight fractions is feasible for ultracentral NSCLC.
Source: Thoracic Cancer - Category: Cancer & Oncology Authors: Tags: ORIGINAL ARTICLE Source Type: research
Conclusions: Treatment of patients with advanced GC/GEJC with PD-1/PD-L1 targeted did result in an improvement in some but not all survival endpoints. Moreover, it had a comparable toxicity profile as compared with chemotherapy alone. More well designed studies are needed to develop a database of all anti-PD1/PD-L1 sub-groups and their individual impact on the differing anti-PD1/PD-L1 treatments.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Conclusions: Contemporary TP in EB allows one to adjust the dose distribution for individual clinical situations and allows one to improve clinical target volume (CTV) coverage, increase doses to the OAR and increase overall survival. The use of new methods of treatment plans in EB has significantly increased the follow-up to 21 months in a treated group of patients. PMID: 31749856 [PubMed]
Source: Journal of Contemporary Brachytherapy - Category: Cancer & Oncology Tags: J Contemp Brachytherapy Source Type: research
CONCLUSION: Our results show a more dominant dose-volume effect in the CHARTWEL arm compared to conventional fractionation, especially for higher esophageal doses. These findings support the notion that dose-volume parameters for radiation esophagitis determined in a specific and time dependent setting of field arrangements can not be easily transferred to another setting. In clinical practice esophageal volumes receiving 40 Gy or more should be strictly limited in hyperfractionated-accelerated fraction schemes. PMID: 31767470 [PubMed - as supplied by publisher]
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - Category: Radiology Authors: Tags: Radiother Oncol Source Type: research
Non-small cell lung cancer (NSCLC) is one of the most common malignant diseases worldwide [4]. Simultaneous radiochemotherapy in the treatment of locally advanced lung cancer yields better outcome than radiotherapy alone [8]. While this treatment regimen is the standard of care, it is also evoking more side effects [8,13]. One of the frequent side effects is early radiation-induced esophageal toxicity (RIET), which can be a reason for treatment interruptions. Complete avoidance of esophagus irradiation in lung cancer radiotherapy is impossible due to several factors: the large, irregularly shaped and centrally located lung...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
The aim of the current study was to investigate the factors contributing to exertional dyspnea in individuals who received thoracic surgery with curative intent for non-small cell lung cancer (NSCLC). It was hypothesized that greater neuromechanical uncoupling (NMU: an imbalance between ventilatory effort and output) would result in greater dyspnea and exercise intolerance in NSCLC. Using a cross-sectional design, postsurgical NSCLC patients (n=22) performed a pulmonary function test, an incremental cycling cardiopulmonary exercise test (CPET) and constant-load exercise at 75% maximum work rate to symptom limitation. Dyspn...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Clinical respiratory physiology, exercise and functional imaging Source Type: research
Brivanib is a selective inhibitor of vascular endothelial growth factor and fibroblast growth factor (FGF) signalling. We performed a phase II randomised discontinuation trial of brivanib in 7 tumour types (soft-tissue sarcomas  [STS], ovarian cancer, breast cancer, pancreatic cancer, non-small-cell lung cancer [NSCLC], gastric/esophageal cancer and transitional cell carcinoma [TCC]).
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: Original Research Source Type: research
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