Clinical characteristics and outcomes of SDHB -related pheochromocytoma and paraganglioma in children and adolescents

ConclusionThe present report has highlighted several important aspects in the management of pediatric patients withSDHB mutations associated-PHEO/PGL. Initial diagnostic evaluation ofSDHB mutation carriers should be started at age of 5 –6 years with initial work-up focusing on abdominal region. Thorough follow-up is crucial first 2 years post-diagnosis and more frequent follow-ups are needed in years 10–20 post-diagnosis due to the increased risk of metastases. Although this age group developed metastasis as early as 5 year s from diagnosis, we have shown that the overall 20-year prognosis and survival are good.
Source: Journal of Cancer Research and Clinical Oncology - Category: Cancer & Oncology Source Type: research