GSE94925 Hydrogen incubation on the mechanical injury of spinal cord neurons

We report the application of mRNA sequencing technology for high-throughput profiling of genes expression changes in spinal cord neurons with or without hydrogen incubation.In model group, we mechanically injured neurons. In control group, neurons were cultured without any intervention. In treatment group, after neurons were injured mechanically, hydrogen incubation(75%) was performed.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

Related Links:

The hypothalamus–pituitary–adrenal (HPA) axis acts to release cortisol into the blood stream, as cortisol calls the body into action to combat stress. When high amounts of cortisol interact with the hypothalamus, the HPA axis will slow down its activity. The amygdala detects stress, while the prefrontal cortex regulates our reactions to stress. Source: Bezdek K and Telzer E (2017) Have No Fear, the Brain is Here! How Your Brain Responds to Stress. Front. Young Minds. 5:71. doi: 10.3389/frym.2017.00071 _______ [Editor’s note: Continued from yesterday’s Exploring the human brain and how it responds to...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Education & Lifelong Learning Health & Wellness #WorldHealthDay brain burnout cognition Cortisol GAS General Adaptation Syndrome homeostasis memory neurobiology neurological exhaustion Stress Source Type: blogs
In this study, we tried to assess the modulatory effect of (S)-3,4-Dicarboxyphenylglycine (DCPG), a metabotropic glutamate receptor subtype 8 (mGluR8) agonist, in a model of chronic central neuropathic pain in male rats. We used a spinal cord contusion method (T6-T8) for the induction of chronic central neuropathic pain.Male Wistar rats were randomly assigned to 5 equal groups (n = 10 per group). Clips compression injury model was used to induce chronic central neuropathic pain. Three weeks after spinal cord injury DCPG, siRNA and normal saline were administered intra-ventrolaterally to the periaqueductal gray (P...
Source: Neurological Research - Category: Neurology Tags: Neurol Res Source Type: research
Cannabinoid-2 receptor (CB2R) plays an important role in the cascading inflammation following ischemic injury. The toll-like receptors 4 (TLR4)/matrix metalloproteinase 9 (MMP9) signal pathway is involved in b...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
A 77-year-old woman presented with positive fecal occult blood test. Her medical history included non-insulin dependent diabetes mellitus, hypertension, and spinal cord injury with myelopathy. Physical examination revealed no abdominal distention, local tenderness, or rebounding pain. Patient's cell blood count showed neither leukocytosis nor anemia. Colonoscopy revealed multiple variably sized submucosal cysts from the descending to the ascending colon (Fig. 1A). When they were biopsied after having filled the colon with water, air bubbles leaked through the biopsy orifice (Fig.
Source: Digestive and Liver Disease - Category: Gastroenterology Authors: Tags: Image of the Month Source Type: research
Publication date: Available online 4 April 2020Source: Life SciencesAuthor(s): Long Xu, Yin-Yao Tang, Xing-Lei Ben, Mao-Hua Cheng, Wei-Xiao Guo, Yun Liu, Zheng-Feng Lu, Jie-Lin Deng
Source: Life Sciences - Category: Biology Source Type: research
CONCLUSIONS: 1. SCI individuals suffer mostly from lack of dynamic stability, which does not depend on their lesion levels. 2. It seems that this problem may be due to rehabilitation methods used to improve stability in these patients. 3. It is recommended that new methods of rehabilitation or assistive devices should be used to improve stability of these individuals. PMID: 32242525 [PubMed - in process]
Source: Ortopedia Traumatologia Rehabilitacja - Category: Orthopaedics Tags: Ortop Traumatol Rehabil Source Type: research
Authors: Sato KL, Sanada LS, Silva MDD, Okubo R, Sluka KA Abstract Background: Transcutaneous electrical nerve stimulation (TENS), manual acupuncture (MA), and spinal cord stimulation (SCS) are used to treat a variety of pain conditions. These non-pharmacological treatments are often thought to work through similar mechanisms, and thus should have similar effects for different types of pain. However, it is unclear if each of these treatments work equally well on each type of pain condition. The purpose of this study was to compared the effects of TENS, MA, and SCS on neuropathic, inflammatory, and non-inflammatory ...
Source: Korean Journal of Pain - Category: Anesthesiology Tags: Korean J Pain Source Type: research
Conclusion: These findings indicated that individuals with greater sensory and motor loss had an increased risk of developing additional pressure injuries compared to individuals with less impairment. These results are meaningful for stakeholders interested in understanding factors associated with developing subsequent pressure injuries during the index rehabilitation stay and provide a foundation for future research in this area. PMID: 32233917 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
This study was designed to identify variables independently associated with prostate volume in men with chronic SCI.MethodsIn this cross-sectional study, prostate volume of 138 men with chronic (>  1 years) SCI, aged 54.5 (25th–75th percentile: 36.0–66.0) years, was evaluated with trans-rectal ultrasonography. All patients underwent a complete neurological exam, as well as biochemical and hormonal assessment, including total testosterone (TT) levels. Free testosterone levels were calcu lated (cFT) by the Vermeulen formula.ResultsThe median prostate volume was 23.4  mL. At the univariate anal...
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Authors: Sengupta M, Gupta A, Khanna M, Rashmi Krishnan UK, Chakrabarti D PMID: 32235290 [PubMed]
Source: Asian Spine Journal - Category: Orthopaedics Tags: Asian Spine J Source Type: research
More News: Brain | Genetics | Neurology | Spinal Cord Injury