GSE145314 Loss of Tmem106b leads to myelination deficits: implications for FTD treatment strategies

Contributors : Xiaolai Zhou ; Alexandra M Nicholson ; Yingxue Ren ; Mieu Brooks ; Peizhou Jiang ; Aamir Zuberi ; Hung N Phuoc ; Ralph B Perkerson ; Billie Matchett ; Tammee M Parsons ; NiCole A Finch ; Wenlang Lin ; Wenhui Qiao ; Monica Castanedes-Casey ; Virginia Phillips ; Ariston L Librero ; Yan Asmann ; Guojun Bu ; Melissa E Murray ; Cathleen Lutz ; Dennis W Dickson ; Rosa RademakersSeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusGenetic variants that define two distinct haplotypes at the TMEM106B locus have been implicated in multiple neurodegenerative diseases and in healthy brain aging. In frontotemporal dementia (FTD), the high expressing TMEM106B risk haplotype was shown to increase susceptibility for FTD with TDP-43 inclusions (FTD-TDP) and to modify disease penetrance in progranulin mutation carriers (FTD-GRN). To further elucidate the biological function of TMEM106B and determine whether lowering TMEM106B may be a viable therapeutic strategy, we performed brain transcriptomic analyses in 8-month-old animals from our recently developed Tmem106b-/- mouse model. We included 10 Tmem106b+/+ (WT), 10 Tmem106b+/- and 10 Tmem106-/- mice. The most differentially expressed genes (153 down-regulated and 60 upregulated) were identified between Tmem106b-/- and WT animals, with an enrichment for genes implicated in myelination-related cellular processes including axon ensheathment and oligodendrocyte differentiation. Co-expression analysis...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research

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Authors: Matsumura E, Nohara K, Tanaka N, Fujii N, Sakai T Abstract Polypharmacy in elderly persons living at home or in a nursing home is an issue. In the field of dentistry, strategies to reduce polypharmacy must be promoted; however, there is insufficient basic data on medications received by elderly persons with dysphagia living at home or in a nursing home. The subjects were 106 elderly persons with dysphagia living at home or in a nursing home. Based on their medical records, the presence of disease and number/type of drugs being administered were investigated. Stroke, dementia, and hypertension were common. ...
Source: Journal of oral science - Category: Dentistry Tags: J Oral Sci Source Type: research
Conditions:   Dementia;   Alzheimer Disease;   Caregiver Burnout Interventions:   Behavioral: CARE-Well App;   Behavioral: Internet Links Sponsors:   Rhode Island Hospital;   University of Rhode Island Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study is consistent with other research, as well as with reports from physicians who recommend cannabis in their daily practices. What might be behind this trend? A confluence of factors seems to be responsible, including the decrease in stigma associated with cannabis use and the increased interest in the use of medical marijuana by older patients. Stigma is a complicated issue, but most would agree that the stigma associated with cannabis use is lessening, especially for medical cannabis. In a recent poll, 94% of Americans voiced support for legal access to medical marijuana, and most states have approved some form ...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Healthy Aging Marijuana Pain Management Source Type: blogs
This article explores live discharge from hospice for caregivers of adults with dementia through a theoretical lens of Symbolic Interactionism (SI) and Attachment Theory (AT). The theories of SI and AT support and assist in understanding the experience of caregivers who lose hospice support due to ineligibility. In addition, caregivers watch the gradual deterioration and psychological loss of someone with dementia while they remain alive described as an ambiguous loss. Ambiguous loss as a subset of traditional bereavement theories provides a framework for this exploration and provides a relevant illustration of the complex...
Source: Journal of Social Work in End-of-Life and Palliative Care - Category: Palliative Care Tags: J Soc Work End Life Palliat Care Source Type: research
Functional MR images (fMRI) have uncovered decreased connectivity from excessive...Read more on AuntMinnie.comRelated Reading: MRI data show smoking, alcohol age the brain Brain MRI may predict alcohol abuse in teens PET, fMRI shed light on alcohol's effects on brain MRI links lifestyle factors to stroke, dementia risk fMRI shows what makes an angry drunk
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
(University of California - Santa Barbara) In the fight against neurodegenerative diseases such as frontotemporal dementia, Alzheimer's and Chronic Traumatic Encephalopathy, the tau protein is a major culprit. Found abundantly in our brain cells, tau is normally a team player -- it maintains structure and stability within neurons, and it helps with transport of nutrients from one part of the cell to another.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Conclusions: The results of this study suggest a difference in perspective between the more optimistic view of persons with dementia and their informal caregivers and the more critical view of physiotherapy experts regarding the most important factors that influence PA participation. In addition, there was a strong focus on the individual characteristics that influence PA behavior that warrant personalized interventions to promote PA in persons with dementia.
Source: Journal of Geriatric Physical Therapy - Category: Physiotherapy Tags: Research Reports Source Type: research
Heart failure, ischemic heart disease, stroke may contribute to link between air pollution and dementia
Source: The Doctors Lounge - Psychiatry - Category: Psychiatry Tags: Cardiology, Family Medicine, Geriatrics, Internal Medicine, Neurology, Psychiatry, Pulmonology, Journal, Source Type: news
Mrs. S is an 85-year-old woman who moved into the nursing home five years ago when her husband could no longer provide care for her due to her progressive weakness and failure to thrive. She has a history of Barrett ’s esophagus and significant reflux and subsequent dysphagia, a long history of depression, allergic rhinitis, dementia with a Brief Interview for Mental Status (BIMS) score of 12, basal cell carcinoma, insomnia, iron deficiency anemia, and a pneumonitis due to aspiration. She is oxygen dependent.
Source: Caring for the Ages - Category: Health Management Authors: Tags: Interdisciplinary Team Case Studies Source Type: news
Hospitals can be dangerous places for older adults. One of these dangers is inappropriate medications — the most common of which is proton pump inhibitors (PPIs). Patients who are discharged taking a PPI often continue to receive it after their admission to a skilled nursing facility. But care needs to be taken: if the PPI is inappropriate, it must be discontinued. As this article highlights, PPIs have many risks to be considered when assessing their continued use with long-term care patients.
Source: Caring for the Ages - Category: Health Management Authors: Source Type: news
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