Flexible platinum electrodes as electrochemical sensor and immunosensor for Parkinson's disease biomarkers.
In this study, platinum electrodes were fabricated on the bio-based poly(ethylene terephthalate) (Bio-PET) substrates for the development of flexible electrochemical sensors for the detection of Parkinson's disease biomarkers. Dopamine was detected by voltammetric measurements, displaying a 3.5 × 10-5 mol L-1 to 8.0 × 10-4 mol L-1 linear range with a limit of detection of 5.1 × 10-6 mol L-1. Parkinson's disease protein 7 (PARK7/DJ-1) was successfully detected by electrochemical impedance spectroscopy after electrode functionalization with specific anti-PARK7/DJ-1 antibodies. In this case, analytical curves presented a linear behavior from 40 ng mL-1 to 150 ng mL-1 of PARK7/DJ-1 with a limit of detection of 7.5 ng mL-1. Besides, the electrodes did not suffer any change in the electrochemical response after manual tests of mechanical tension. The proposed sensor and immunosensor were applied for the determination of Parkinson's disease biomarkers concentrations found in the human body, being adequate as an alternative method to diagnose this disease. PMID: 32056736 [PubMed - in process]
Condition: Parkinson Disease Intervention: Drug: IZD174 Sponsor: Inflazome UK Ltd Not yet recruiting
Authors: Femat-Roldán G, Gaitán Palau MA, Castilla-Cortázar I, Elizondo Ochoa G, Moreno NG, Martín-Estal I, Jiménez Yarza M Abstract Background: Weight loss in Parkinson's disease (PD) patients is a common but poorly understood manifestation. Several studies have reported that weight changes could be related to motor symptoms, drug side effects, dysphagia, depression, and/or dementia. Weight loss in PD is not a benign phenomenon and it has several clinical and prognostic implications with increased morbidity and mortality. Thus, it is crucial to determine nutritional changes in PD...
Conclusions: LCIG may affect PDrPD and reduce premature bolus spillage and pharyngeal bradykinesia. Future studies with larger sample sizes are required to follow-up on these pilot results and identify which factors predict a good response of PDrPD to LCIG treatment. PMID: 32257098 [PubMed - as supplied by publisher]
Authors: Scialò C, Legname G PMID: 32253950 [PubMed - as supplied by publisher]
CONCLUSION: Optimal training duration was relatively short and the IPD group demonstrated the most gain, indicating that cognitive training should be tailored to individual needs. PMID: 32250326 [PubMed - as supplied by publisher]
Authors: Macerollo A, Zrinzo L, Akram H, Foltynie T, Limousin P Abstract Over the last three decades, extensive basic and clinical research has been performed on the use of subthalamic nucleus (STN) as the preferred deep brain stimulation (DBS) target for the treatment of Parkinson's disease (PD). The mechanism underlying the benefit for the motor symptoms in PD is related to the modulation of firing patterns within the hyperdirect projections from motor cortical areas, as well as within the afferent and efferent fibers to the motor STN. Advancements in neuroimaging techniques allow us to identify precisely the STN...
(University of Virginia Health System) The finding also could have important implications for a wide range of neurodegenerative diseases, such as Alzheimer's and Parkinson's.
Publication date: June 2020Source: Molecular Genetics and Metabolism Reports, Volume 23Author(s): M.M. Rudenok, A.Kh. Alieva, J.S. Starovatykh, M.S. Nesterov, V.A. Stanishevskaya, A.A. Kolacheva, M.V. Ugryumov, P.A. Slominsky, M.I. Shadrina
Conclusion: These findings suggest that laquinimod treatment might be a possible therapeutic strategy for neuroinflammation in PD. PMID: 32249647 [PubMed - as supplied by publisher]
The TMEM175 family constitutes recently discovered K+ channels that are important for autophagosome turnover and lysosomal pH regulation and are associated with the early onset of Parkinson Disease. TMEM175 channels lack a P-loop selectivity filter, a hallmark of all known K+ channels, raising the question how selectivity is achieved. Here, we report the X-ray structure of a closed bacterial TMEM175 channel in complex with a nanobody fusion-protein disclosing bound K+ ions. Our analysis revealed that a highly conserved layer of threonine residues in the pore conveys a basal K+selectivity. An additional layer comprising two...