Early increment of soluble triggering receptor expressed on myeloid cells 2 in plasma might be a predictor of poor outcome after ischemic stroke

Publication date: Available online 14 February 2020Source: Journal of Clinical NeuroscienceAuthor(s): Hyuk Sung Kwon, Eun-Hye Lee, Hyun-Hee Park, Jeong-Hwa Jin, Hojin Choi, Kyu-Yong Lee, Young Joo Lee, Jae-Hong Lee, Felipe Marques Souza de Oliveira, Hyun Young Kim, Young Seo Kim, Bum Joon Kim, Sung Hyuk Heo, Dae-Il Chang, Masood Kamali-Moghaddam, Seong-Ho KohAbstractSoluble triggering receptor expressed on myeloid cells 2 (sTREM2) is derived from cleavage of TREM2, which is expressed on the cell surface of microlgia and other tissue-specific macrophages. In the present study, the changes in the sTREM2 levels after ischemic stroke (IS) and their association with clinical outcomes were evaluated. A total of 43 patients diagnosed with non-cardioembolic IS between June 2011 and May 2014 were consecutively included in this study. Patients treated with intravenous thrombolysis or intra-arterial thrombectomy were excluded. Plasma samples were collected three times (days 1, 7, and 90) after ictus. The sTREM2 level was measured in the samples using the highly sensitive solid-phase proximity ligation assay (SP-PLA). Among the 43 subjects, higher initial NIH stroke scale (NIHSS) score (P = 0.005), early increment of sTREM2 (P < 0.001), and late decrement of sTREM2 (P = 0.002), were more common in patients with poor outcome. Based on multivariate analysis, initial NIHSS score (P = 0.015) and early increment of sTREM2 (P = 0.032) were independently associated with poor outco...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research