Histopathological, genotoxic, and behavioral damages induced by manganese (II) in adult zebrafish.

Histopathological, genotoxic, and behavioral damages induced by manganese (II) in adult zebrafish. Chemosphere. 2020 Apr;244:125550 Authors: Zimmermann Prado Rodrigues G, Staudt LBM, Moreira MG, Dos Santos TG, de Souza MS, Lúcio CJ, Panizzon J, Kayser JM, Simões LAR, Ziulkoski AL, Bonan CD, de Oliveira DL, Gehlen G Abstract Manganese is a metal often found as an environmental pollutant and very associated with neurological disorders when in high concentrations. However, little is known about the effects that this contaminant can cause when in environmentally relevant concentrations and occurrence, that is, much lower than those commonly studied. So, the aim of the study was to evaluate the effects that environmentally relevant concentrations of this metal would cause in different zebrafish organs (brain, liver, and blood). Acute 96-h and chronic 30-day exposures were performed using the manganese chloride salt as a pollutant. Behavioral alterations of anxiogenic type were observed in the animals after chronic exposures to 4.0 mg L-1 MnCl2, which traveled a greater distance at the bottom of the aquarium. This may be associated with neuronal damages in the telencephalic region responsible for motor and cognitive activity of the fish, observed in animals from the same exposure. In addition, hepatic histopathological damage as vacuolization of hepatocytes and genotoxic damage, identified by comet assay and micronucleus test, was also...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research