Interval Exercise Lowers Circulating CD105 Extracellular Vesicles in Prediabetes

Conclusions Interval exercise training decreases endothelial-derived EV in adults with prediabetes. Although increased sugar consumption may alter EV after a short-term exercise intervention, fitness modifies EV count.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: APPLIED SCIENCES Source Type: research

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Publication date: Available online 7 April 2020Source: Academic PediatricsAuthor(s): Marcela Osorio, Christian A. Koziatek, Mary Pat Gallagher, Jessie Recaii, Meryle Weinstein, Lorna E. Thorpe, Brian Elbel, David C. Lee
Source: Academic Pediatrics - Category: Pediatrics Source Type: research
AbstractPurposeThe utility of available scoring systems for type 2 diabetes (T2D) remission prediction after metabolic surgery has not been defined in a multi-ethnic Asian population like Singapore. We sought to assess the predictive performance of the Asia-developed ABCD scoring system for T2D remission after metabolic surgery, and develop a new algorithm to improve prediction.Materials and MethodsWe conducted a retrospective analysis of adults with T2D who underwent either Roux-en-Y gastric bypass or sleeve gastrectomy between 2007 and 2018, and followed for 1  year postoperatively (n = 114, mean age 4...
Source: Obesity Surgery - Category: Surgery Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
CONCLUSIONS These results indicate that GDLP against T2DM-induced hepatic steatosis, oxidative stress, and inflammation by improving the Nrf2/HO-1 signaling pathway in db/db mice, suggesting the GDLP may serve as an effective strategy for in fatty liver treatment. PMID: 32245940 [PubMed - as supplied by publisher]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Abstract BACKGROUND: Health-related quality of life (HRQL) is an important outcome for chronic diseases such as diabetes mellitus that is associated with complications, comorbidities, and lifelong care. OBJECTIVES: The present study aims to explore the impact of comorbidities on the different dimensions of HRQL among type 2 diabetic patients attending primary care. METHODS: A total of 912 type 2 diabetic patients attending primary care centers in India were assessed using a predesigned and pretested questionnaire - Diabetes Comorbidity Evaluation Tool in Primary Care. The HRQL was measured by physical an...
Source: Primary Care - Category: Primary Care Authors: Tags: Prim Health Care Res Dev Source Type: research
Authors: Popa A, Georgescu M, Popa SG, Nica AE, Georgescu EF Abstract Steadily, cancer is becoming the first cause of mortality, with over 9 million deaths estimated in 2018. Increasing evidence supports a direct association between obesity, type 2 diabetes mellitus (T2DM) and cancer, with a higher risk of cancer mortality especially for some of the most common malignancies, such as breast, colon, and rectal cancers. So far, several mechanisms underlying the cancer-diabetes relationship have been investigated revealing dysregulations of the insulin-insulin-like growth factor (IGF) system as the most important parad...
Source: Romanian Journal of Morphology and Embryology - Category: General Medicine Tags: Rom J Morphol Embryol Source Type: research
Source: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy - Category: Endocrinology Tags: Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Source Type: research
AbstractTestosterone (T) plays a pivotal role in coordinating a series of psychological, cognitive and physical events that might (or might not) culminate in male sexual activity. In fact, T deficiency is associated, in a statistically significant way, with several sexual dysfunctions including erectile dysfunction (ED), reduction of spontaneous erection and hypoactive sexual desire (HSD). Although these associations are statistically significant, there is debate if they are also clinically meaningful. In addition, sexual dysfunctions are present also in several metabolic conditions ‐ such as type 2 diabetes mellitus and...
Source: Andrology - Category: Urology & Nephrology Authors: Tags: REVIEW ARTICLE Source Type: research
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Source: Molecular Nutrition and Food Research - Category: Food Science Authors: Tags: Review Source Type: research
AbstractIn the past few decades, the prevalence of obesity has increased not only in Western countries but also in Asia. Obesity is frequently accompanied by unhealthy adipocyte expansion; this results in a condition known as metabolic abnormal obesity, in which lipid spillover and abnormal adipocytokine secretion from adipose tissue elicit insulin resistance, a hallmark of type 2 diabetes mellitus1. In addition, several studies have suggested that metabolic abnormal obesity may contribute to the development of pancreatic β cell failure, another hallmark of Type 2 diabetes (Figure 1). Although most clinical data suppo...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: JDI UPDATES Source Type: research
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