Satisfaction, fulfillment of expectations and adherence to subcutaneous biological drugs in patients with rheumatoid arthritis: ARCO study

ConclusionsSatisfaction and fulfilment of expectations were high. Fulfilment of expectations of tolerability was better with monthly administration, which could contribute to better adherence.ResumenObjetivosEn el estudio ARCO, la adherencia al biológico subcutáneo en pacientes con artritis reumatoide fue mejor con administración mensual. Evaluamos si satisfacción y cumplimiento de expectativas pueden relacionarse con la adherencia al tratamiento.Pacientes y métodosLa adherencia se evaluó calculando el Índice de Posesión de Medicación, y satisfacción y cumplimiento de expectativas mediante el cuestionario EXPRESAR.ResultadosEn 346 pacientes, los porcentajes satisfechos/muy satisfechos con eficacia y tolerabilidad fueron ≥80% y 64.4%, sin diferencias entre pautas semanal, cada dos semanas o mensual. Sobre el cumplimiento de expectativas, el 59.9% consideró el efecto del tratamiento mayor al esperado, y el 52.6% las molestias bastante/mucho menores a las esperadas, porcentaje mayor en pacientes con administración mensual p = 0,049. Los porcentajes de no-adherencia fueron 15.6% (molestias mayores a las esperadas), 18.5% (molestias esperadas) y 11.1% menores/sin molestias p = 0,189.ConclusionesLa satisfacción y el cumplimiento de expectativas fueron altos. El cumplimiento de expectativas de tolerabilidad fue mejor con administración mensual, lo que podría contribuir...
Source: Reumatologia Clinica - Category: Rheumatology Source Type: research

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Authors: Wang B, Chen S, Zheng Q, Liu Y, Shi G Abstract Rheumatic diseases are extremely heterogeneous diseases with substantial risks of morbidity and mortality, and there is a pressing need in developing more safe and cost-effective treatment strategies. Peptide-based vaccination is a highly desirable strategy in treating noninfection diseases, such as cancer and autoimmune diseases, and has gained increasing attentions. This review is aimed at providing a brief overview of the recent advances in peptide-based vaccination therapy for rheumatic diseases. Tremendous efforts have been made to develop effective pepti...
Source: Journal of Immunology Research - Category: Allergy & Immunology Tags: J Immunol Res Source Type: research
Authors: Zhao F, Zhang WD, Jiang YL, Liu W, Cao J PMID: 32253899 [PubMed - in process]
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Conclusion and implications: Our results suggest that cholinergic agonists can modulate pathological conditions related to pannus formation in in-vitro conditions. Based on these results, cholinergic agonists can be considered as novel therapeutic options in RA. Further animal studies are needed before introducing these agents into clinical uses. PMID: 32248717 [PubMed - as supplied by publisher]
Source: Immunopharmacology and Immunotoxicology - Category: Allergy & Immunology Tags: Immunopharmacol Immunotoxicol Source Type: research
This study aimed to investigate methotrexate (MTX)-related toxicity in patients with rheumatoid arthritis (RA) and renal dysfunction. This retrospective cohort study included patients with RA and renal dysfunction. Renal dysfunction was defined as an estimated glomerular filtration rate (eGFR) of  
Source: Rheumatology International - Category: Rheumatology Source Type: research
AbstractAssessment of individual therapeutic responses provides valuable information concerning treatment benefits in individual patients. We evaluated individual therapeutic responses as determined by the Disease Activity Score-28 joints critical difference for improvement (DAS28-dcrit) in rheumatoid arthritis (RA) patients treated with intravenous tocilizumab or comparator anti-tumor necrosis factor (TNF) agents. The previously published DAS28-dcrit value [DAS28 decrease (improvement)  ≥ 1.8] was retrospectively applied to data from two studies of tocilizumab in RA, the 52-week ACT-iON observational stud...
Source: Rheumatology International - Category: Rheumatology Source Type: research
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Source: Psychology, Health and Medicine - Category: International Medicine & Public Health Authors: Source Type: research
ConclusionsTGF- β1 polymorphism is associated with disease activity of RA. Disease activity is strongly modulated in the presence of serum RF and TGF-β1 polymorphism.Key Points•TGF-β1 +869C/T polymorphism was found to be associated with RA in the patients.•The polymorphism showed significant association with all inflammatory parameters as ESR, CRP, and DAS-28 in RA subjects.•RF negative patients showed high ESR, CRP, and swollen joint count with TT genotype.•TGF-β1 polymorphism and serum RF are modulating disease activity in RA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
US president called Modi and threatened ‘retaliation’ if country kept full export banCoronavirus – latest updatesSee all our coronavirus coverageIndia has approved some exports ofhydroxychloroquine, an anti-malaria drug being touted as a possible coronavirus treatment, after apparent pressure from Donald Trump, who has been urging Americans to take it.The tablets are used to prevent and treat malaria, lupus and rheumatoid arthritis but over the past week the US president has been aggressively promoting the drug as a treatment for coronavirus, despite there being no conclusive medical evidence to prove its...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: India South and Central Asia World news US news Malaria Coronavirus outbreak Infectious diseases Medical research Science Source Type: news
Interleukin-6 (IL-6) is a pleiotropic cytokine that plays a key role in the pathogenesis of rheumatoid arthritis. Sarilumab is a human monoclonal antibody that binds membrane-bound and soluble IL-6 receptor- α ...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Felty ’s syndrome (FS) is characterized by the triad of rheumatoid arthritis (RA), splenomegaly and neutropenia. The arthritis is typically severe and virtually always associated with high-titer rheumatoid fact...
Source: BMC Pediatrics - Category: Pediatrics Authors: Tags: Case report Source Type: research
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