Being active may improve radiation therapy outcomes

Patients who are physically active before they undergo thoracic radiation therapy...Read more on AuntMinnie.comRelated Reading: ASTRO, ACR update RT practice parameters RT improves elderly brain cancer patient survival IMV: Imaging boosts precision in radiation therapy ASTRO: Whole, partial breast RT yield similar cosmetic results Varian to highlight RT management system at AAPM meeting
Source: Headlines - Category: Radiology Source Type: news

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The authors conducted a multicenter retrospective study on the outcome of programmed death-ligand 1 tumor proportion score≥50% advanced non–small cell lung cancer patients treated with first-line pembrolizumab according to the presence/absence of brain metastases. A total of 282 patients were included, of whom 56 had brain metastases that were treated with upfront local radiation therapy in 80.3% of cases. The overall response rate was 39.2% and 44.4% in patients with and without brain metastases (P=0.48), respectively, while intracranial response rate and intracranial disease control rate were 67.5% and 85.0%, re...
Source: Journal of Immunotherapy - Category: Allergy & Immunology Tags: Clinical Studies Source Type: research
CONCLUSIONS: Charged particle therapy with controlled beams of protons and carbon ions have significantly impacted targeted cancer therapy, eradicated tumors while sparing normal tissue toxicities, and reduced human suffering. These modalities still require further optimization and technical refinements to reduce cost but should be made available to everyone in need worldwide. The exploration of our Universe in space travel poses the potential risk of exposure to uncontrolled charged particles.However, approaches to shield and provide countermeasures to these potential radiation hazards in LEO have allowed an amazing numbe...
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
i In patients with renal cell carcinoma, brain metastasis is generally one of the poor prognostic factors. However, the recent introduction of molecular target therapy and immune checkpoint inhibitor has remarkably advanced the systemic treatment of metastatic renal cell carcinoma and prolonged the patients’ survival. The pivotal clinical trials of those agents usually excluded patients with brain metastasis. The incidence of brain metastasis has been increasing in the actual clinical setting because of longer control of extra-cranial disease. Brain metastasis subgroup data from the prospective and retrospect...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
In the absence of clear interstitial invasion, encapsulated papillary carcinoma (EPC) of the breast may be attributed to an extremely good prognosis if handled similarly to ductal carcinoma in situ (DCIS) with suitable local treatment. Here, we report our experience with a case of EPC of the breast that presented with carcinomatous pleuritis and lymphangitis carcinomatosa postoperatively, which rapidly resulted in a poor outcome. A 67-year-old woman was diagnosed with DCIS of the left breast and underwent left partial mastectomy and sentinel lymph node biopsy. EPC was diagnosed because the pathological examination showed n...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
The sonic hedgehog subtype of medulloblastoma (SHH MB) is associated with treatment failure and poor outcome. Current strategies utilizing whole brain radiation therapy result in deleterious off-target effects on the normal developing childhood brain. Most conventional chemotherapies remain limited by ineffective blood–brain barrier (BBB) penetrance. These challenges signify an unmet...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Biological Sciences Source Type: research
Brain tumors are the most common solid cancer in children younger than 15 years old.[1] Radiation therapy (RT) remains integral to the treatment of pediatric brain tumors, having significantly improved disease prognosis for common malignant tumors such as medulloblastomas: in average-risk disease, the 5-year survival for these tumors is now at 70-80%.[2,3] Elevated 5-year survival rates have also been achieved through the use of RT as a stand-alone therapy in the treatment of germinomas.[4] Despite having contributed to the overall survival benefit experienced by patients, such therapeutic approaches are associated with lo...
Source: Radiotherapy and Oncology - Category: Radiology Authors: Tags: Original Article Source Type: research
This study has thus identified a simple transcriptome signature for GBM prognosis. PMID: 32931454 [PubMed - as supplied by publisher]
Source: Aging - Category: Biomedical Science Authors: Tags: Aging (Albany NY) Source Type: research
Conclusion: Initial treatment of BM with SRS may offer comparable local and distant intracranial control to SR in patients with single or solitary BM. OS did not significantly differ between the SR and SRS groups in people with single or solitary BM.Stereotact Funct Neurosurg
Source: Stereotactic and Functional Neurosurgery - Category: Neurosurgery Source Type: research
This report describes the usefulness of relatively low-dose WBRT for ill-defined CNS-MZL.
Source: International Cancer Conference Journal - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Our results suggest that AsiDNA is an attractive candidate to improve radiation therapy in MB, with no indication of additional toxicity in developing brain tissues. PMID: 32900798 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - Category: Cancer & Oncology Authors: Tags: Clin Cancer Res Source Type: research
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