Matched-pair analysis of transplant from haploidentical, unmanipulated bone marrow donor versus hla identical sibling for patients with hematological malignancies

For many years, the main alternative for patients lacking an HLA-matched family donor has been an 8/8 HLA antigen matched unrelated donor (MUD) allocated through the International Registries of volunteer donors.1,2 However, despite the number of such volunteers exceeds 30 million,3,4 almost two thirds of patients do not proceed to transplantation. The enormous variability of HLA polymorphisms and the time required for identifying a suitable donor are the two most important factors limiting the use of MUD transplant, especially for patients at high risk of disease progression who are in urgent need of being transplanted.

Source: Biology of Blood and Marrow Transplantation - February 13, 2020 Category: Hematology Authors: William Arcese, Raffaella Cerretti, Loredana Sarmati, Laura Cudillo, Gottardo De Angelis, Benedetta Mariotti, Antoine Bruno, Ilaria Mangione, Cristina Rapanotti, Marco Andreani, Paolo De Fabritiis, Teresa Dentamaro, Luca Cupelli, Andrea Mengarelli, France Source Type: research