Cancers, Vol. 12, Pages 448: Impact of Age-Related Genetic Differences on the Therapeutic Outcome of Papillary Thyroid Cancer

Cancers, Vol. 12, Pages 448: Impact of Age-Related Genetic Differences on the Therapeutic Outcome of Papillary Thyroid Cancer Cancers doi: 10.3390/cancers12020448 Authors: Seok-Mo Kim Soo Young Kim Cheong Soo Park Hang-Seok Chang Ki Cheong Park The incidence of papillary thyroid carcinoma (PTC) has been increasing worldwide. PTC is the most common type of differentiated thyroid cancer and usually shows good prognosis. However, some PTC is driven to advanced stage by epithelial-mesenchymal transition (EMT)-mediated drug resistance, which is particularly noticeable in pediatric patients. There are limited options for systemic treatment, necessitating development of new clinical approaches. Here, we aimed to clarify genetic differences due to age of patients with PTC, and thereby aid in developing novel therapeutics. Patients with biochemically and histologically confirmed PTC were included in this study. PTC cells were acquired from young and older patients showing drug resistance, and were compared via microarray analysis. Cellular proliferation and other properties were determined after treatments with lenvatinib and sorafenib. In vivo, tumor volume and other properties were examined using a mouse xenograft model. Lenvatinib-treated group showed obvious suppression of markers of anti-apoptosis, EMT, and the FGFR signaling pathway, compared with control and Sorafenib-treated group. In the xenograft models, lenvatinib treatment induced significant tumor shrinkag...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research

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