Neoadjuvant chemotherapy with gemcitabine plus cisplatin followed by radical liver resection versus immediate radical liver resection alone with or without adjuvant chemotherapy in incidentally detected gallbladder carcinoma after simple cholecystectomy or in front of radical resection of BTC (ICC/ECC) – a phase III study of the German registry of incidental gallbladder carcinoma platform (GR)– the AIO/ CALGP/ ACO- GAIN-trial –

Currently, complete surgical resection represents the only potentially curative treatment option for Biliary Tract Cancer (BTC) including Gallbladder Cancer (GBC). Even after curative resection, 5-year OS is o...
Source: BMC Cancer - Category: Cancer & Oncology Authors: Tags: Study protocol Source Type: research

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Rationale: Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare tumor. MiNEN of the gallbladder (GB) with pancreaticobiliary maljunction (PMJ) is extremely rare. The origin of MiNEN of the GB remains unknown; the biliary tract normally lacks neuroendocrine cells. MiNEN of the GB has a poor prognosis; because of its rarity, no treatment or management guidelines have been established yet. Patient concerns: A 47-year-old male presenting with right hypochondrial pain and malaise for 3 months was referred to our hospital for further management. Diagnosis: The neuron-specific enolase level was inc...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Biomed Pharmacother. 2021 Aug 12;142:112025. doi: 10.1016/j.biopha.2021.112025. Online ahead of print.ABSTRACTCircular RNAs (circRNAs) have a closed loop structure which endows them high stability. These transcripts are made through back splicing instead of classical splicing and are abundant in the human transcriptome. Recent advances in the development and implementation of high-throughput sequencing methods in cooperation with novel bioinformatics tools have shown contribution of circRNAs in the developmental processes, physiological settings and pathoetiology of cancers. CircMTO1 is a circRNA which was firstly identifi...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
CONCLUSION: LncRNA DGCR5 might be a viable marker or a promising therapeutic target in digestive system cancers.PMID:34387158 | DOI:10.2174/1381612827666210812130455
Source: Current Pharmaceutical Design - Category: Drugs & Pharmacology Authors: Source Type: research
Am Surg. 2021 Aug 12:31348211038563. doi: 10.1177/00031348211038563. Online ahead of print.ABSTRACTBACKGROUND: Chemotherapy is the standard of treatment for metastatic gallbladder carcinoma (GBC). It is unclear whether chemotherapy plus surgery improves the survival outcomes of patients with isolated liver metastases from GBC. We aimed to investigate the survival benefits of chemotherapy plus surgery in GBC with isolated liver metastases compared to those of chemotherapy alone.METHODS: We identified 406 patients with isolated liver metastases from GBC who underwent chemotherapy alone or chemotherapy plus surgery between 20...
Source: The American Surgeon - Category: Surgery Authors: Source Type: research
CONCLUSIONS: Due to the non specific symptoms patients of GBC present at very advanced stages, high index of suspicion and health education seems to play an important role in early detection and improvement of survival.PMID:34321956 | PMC:PMC8312375 | DOI:10.4103/jcar.JCar_3_21
Source: Journal of Carcinogenesis - Category: Cancer & Oncology Authors: Source Type: research
Conditions:   Incidental Gallbladder Carcinoma;   Biliary Tract Cancer Interventions:   Drug: Gemcitabine;   Drug: Cisplatin;   Procedure: Oncologically radical margin-free (R0) resection;   Drug: Adjuvant chemotherapy Sponsors:   Krankenhaus Nordwest;   German Research Foundation Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Abstract An American Hepato‐Pancreato‐Biliary Association (AHPBA)‐sponsored consensus meeting of expert panellists was convened on 15 January 2014 to review current evidence on the management of gallbladder carcinoma in order to establish practice guidelines. In summary, within high incidence areas, the assessment of routine gallbladder specimens should include the microscopic evaluation of a minimum of three sections and the cystic duct margin; specimens with dysplasia or proven cancer should be extensively sampled. Provided the patient is medically fit for surgery, data support the resection of all gallbladder poly...
Source: HPB: official journal of the International Hepato Pancreat Biliary Association - Category: Gastroenterology Authors: Tags: Original Article Source Type: research
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