Immunological consequences of “immune reconstitution therapy” in multiple sclerosis: A systematic review

Publication date: Available online 13 February 2020Source: Autoimmunity ReviewsAuthor(s): Johann Sellner, Paulus S. RommerAbstractImmune reconstitution therapy (IRT) is an emerging concept for the treatment of multiple sclerosis (MS) that is given intermittently and can induce long-term remission of MS that is sustained in treatment-free periods. A systematic literature review was performed to identify and summarize current knowledge regarding the short- and long-term immunological consequences of different IRTs and CD20 depleting therapies on the cellular level in patients with MS. A total of 586 articles published between January 2010 and September 2019 were identified and screened; 44 studies met inclusion criteria for the review. All the treatments considered appeared to produce both qualitative and quantitative changes in the immune cell populations of patients with MS that resulted in a more anti-inflammatory immune profile. Autologous hematopoietic stem cell transplantation produced the longest-lasting and greatest effects on a wide range of immune cells. Many patients achieved prolonged depletion of the adaptive immune system when alemtuzumab and cladribine tablets were administered as short courses of therapy; however, a proportion of patients required retreatment to maintain these effects. Alemtuzumab may produce greater depletion of both CD4+ and CD8+ T cells than cladribine tablets, although both treatments similarly deplete B cells. Recovery of B cells before T c...
Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research

Related Links:

 Medication for your brain – whether you’re newly diagnosed or have been in treatment for years, you may have doubts if drugs are right for you. You’re not alone. Jackie and Gabe get real about reasons people want to quit psych meds and why our brains convince us to quit despite the benefits of taking medication. They discuss consequences you may not be aware of from just stopping your meds and why you should always involve your doctors, no matter what your decision, when it comes to medication. (Transcript Available Below) SUBSCRIBE &REVIEW About The Not Crazy Podcast Hosts Gabe Howard is an a...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Antidepressant Antipsychotic Medications Not Crazy Podcast Psychology Stimulants Treatment Source Type: blogs
In conclusion, we found a gradient of increasing blood pressure with higher levels of BMI. The fact that this gradient is present even in the fully adjusted analyses suggests that BMI may cause a direct effect on blood pressure, independent of other clinical risk factors. PRRX1 as a Possible Point of Control for Remyelination https://www.fightaging.org/archives/2018/12/prrx1-as-a-possible-point-of-control-for-remyelination/ Researchers here outline what is possibly a new point of intervention in the processes that maintain the myelin sheath that wraps nerves. This sheath is vital to the correct operatio...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
SetPoint Medical has launched a pilot trial to assess the safety and efficacy of a bioelectronics device in patients, who are suffering from rheumatoid arthritis and who are not adequately responsive to multiple biologic agents. The study will enroll a total of 15 subjects, aged 22 to 75, across seven U.S. investigational centers. Valencia, CA-based SetPoint's approach toward treating RA is designed to supplement the body's natural inflammatory reflex by providing "built-in" therapy and is intended to improve safety compared with drugs or biologic solutions. Currently pharmaceutical options are used to treat...
Source: MDDI - Category: Medical Devices Authors: Tags: Digital Health Implants Source Type: news
In conclusion, senescence of vascular cells promotes the development of age-related disorders, including heart failure, diabetes, and atherosclerotic diseases, while suppression of vascular cell senescence ameliorates phenotypic features of aging in various models. Recent findings have indicated that specific depletion of senescent cells reverses age-related changes. Although the biological networks contributing to maintenance of homeostasis are extremely complex, it seems reasonable to explore senolytic agents that can act on specific cellular components or tissues. Several clinical trials of senolytic agents are currentl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Sancho L, Kramer M, Koriat A, Eiger-Moscovich M, Sharon Y, Amer R Abstract PURPOSE: To study the prevalence and time of onset of ocular complications in intermediate uveitis (IU) and to assess their effects on visual outcome in short-term and long-term follow-up. METHODS: A retrospective cohort study of patients with IU who had a minimal follow-up of one year. RESULTS: 96 patients (174 eyes, 70% females) were included with a mean age at presentation of 30 years. Children constituted 38% of all patients. Mean follow- up was 64.9 months. Pars planitis was the most common form followed by sarcoidosis ...
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Robotics has the power to completely reshape the landscape of healthcare both in its structure and its operation. Here, you find my own list about the most relevant companies and start-ups on the healthcare robotics market. With robotics for the sustainability of healthcare As I outlined in my open letter to regulators, the long-term sustainability of healthcare systems could be solved by automation powered by digital health technologies, such as artificial intelligence, 3D-printing or robotics. The latter could take over monotonous work from healthcare workers, which would allow them to focus more on patients and to have ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Medicine Medical Robotics GC1 google Health Healthcare Innovation pharma robot companion surgical robot Source Type: blogs
I had a near-death experience the other day. Well, that’s what Caryn and I are calling it. Truth be known, had I landed four inches to the left of where I did, Caryn, my wife, would have discovered a blood-soaked rug with my lifeless body upon it when she got out of the shower. How I actually fell is unknown to me. All I know is I was upright one moment, and the next I was not. These things must be assessed after the fact and from a position rather ungracefully attained. I took a survey of the parts I could feel, and nothing seemed to be broken. I employed techniques from a previous blog about how to get up...
Source: Life with MS - Category: Neurology Authors: Tags: multiple sclerosis life with MS Living with MS MS and family MS Fitness Symptom management trevis gleason Source Type: blogs
This study provides additional fuel to really bolster research efforts by us and others in geroscience, a field that seeks to understand relationships between the biology of aging and age-related diseases. Aging is the most important risk factor for common chronic conditions such as heart disease, Alzheimer's and cancer, which are likely to share pathways with aging and therefore interventions designed to slow biological aging processes may also delay the onset of disease and disability, thus expanding years of healthy and independent lives for our seniors." Longer-Lived Parents and Cardiovascular Outcomes ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
More News: Allergy & Immunology | Eyes | Hypermetropia (long sighted) | Multiple Sclerosis | Rituxan | Stem Cell Therapy | Stem Cells | Study | Transplants